生物
效应器
合成生物学
转录因子
计算生物学
生化工程
变构调节
化学空间
细胞生物学
药物发现
生物信息学
生物化学
基因
酶
工程类
作者
Vincent Libis,Baudoin Delépine,Jean‐Loup Faulon
标识
DOI:10.1016/j.mib.2016.07.006
摘要
Bacteria rely on allosteric transcription factors (aTFs) to sense a wide range of chemicals. The variety of effectors has contributed in making aTFs the most used input system in synthetic biological circuits. Considering their enabling role in biotechnology, an important question concerns the size of the chemical space that can potentially be detected by these biosensors. From digging into the ever changing repertoire of natural regulatory circuits, to advances in aTF engineering, we review here different strategies that are pushing the boundaries of this chemical space. We also review natural and synthetic cases of indirect sensing, where aTFs work in combination with metabolism to enable detection of new molecules.
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