堆积
卟啉
分子内力
分子间力
氢键
超分子化学
化学
结晶学
自组装
肽
蛋白质二级结构
测试表
超分子手性
福尔达默
J-骨料
立体化学
光化学
分子
有机化学
晶体结构
生物化学
作者
Rui‐hong Liu,Dongzhi Liu,Fancui Meng,Wei Li,Lichang Wang,Xueqin Zhou
标识
DOI:10.1016/j.dyepig.2021.109135
摘要
The stacking mode of aggregates directly determines the morphology and properties of assemblies. However, how the peptide secondary confirmation affects the arrangement of artificial photosynthetic supramolecules is still ambiguous. Herein, a porphyrin-hexapeptide supramolecule TPP-Ala-Ala-MV was synthesized to investigate the effect of its secondary conformation on the stacking mode and morphology of aggregates. Nanosheets, nanospheres and nanotubes were obtained from TPP-Ala-Ala-MV at different pH conditions. It was revealed that the pH condition influences not only the aggregation of porphyrin cores, but also its secondary conformation composition. Both experimental and computational results discover that the hexapeptide α-helix conformation has the strongest intramolecular hydrogen bond interaction, whereas no intermolecular hydrogen bond forms in β-sheet conformation. The inclination to J-aggregation, as well as the weak intermolecular interaction among hexapeptide turn conformation, leads to the formation of nanosheets. The inclination to H-aggregation coupled with the strong intermolecular interaction among hexapeptide β-sheet conformations promotes the formation of a highly packed structure, resulting in aggregates of nanosphere or nanotube shape. These results pave the way for the development of artificial photosynthesis systems by regulating the aggregate structures of porphyrin-peptide supramolecular systems.
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