创伤弧菌
微生物学
弧菌
弧菌感染
生物
副溶血性弧菌
毒力
霍乱弧菌
免疫系统
殖民地化
致病菌
群体感应
细菌
免疫学
基因
生物化学
遗传学
作者
Han Sun,Chunshen Zhu,Xiaodan Fu,Shakir Khattak,Jingyu Wang,Zhihao Liu,Qing Kong,Haijin Mou,Francesco Secundo
标识
DOI:10.3389/fmicb.2022.947767
摘要
Vibrio species are disseminated broadly in the marine environment. Some of them can cause severe gastroenteritis by contaminating seafood and drinking water, such as Vibrio parahaemolyticus, Vibrio cholerae, and Vibrio vulnificus. However, their pathogenic mechanism still needs to be revealed to prevent and reduce morbidity. This review comprehensively introduces and discusses the common pathogenic process of Vibrio including adhesion, cell colonization and proliferation, and resistance to host immunity. Vibrio usually produces pathogenic factors including hemolysin, type-III secretion system, and adhesion proteins. Quorum sensing, a cell molecular communication system between the bacterial cells, plays an important role in Vibrio intestinal invasion and colonization. The human immune system can limit the virulence of Vibrio or even kill the bacteria through different responses. The intestinal microbiota is a key component of the immune system, but information on its effects on physiological metabolism and pathogenicity of Vibrio is seldom available. In this review, the effects of intestinal microorganisms and their metabolites on the invasion and colonization of common pathogenic Vibrio and VBNC status cells are discussed, which is conducive to finding the next-generation prebiotics. The strategy of dietary intervention is discussed for food safety control. Finally, future perspectives are proposed to prevent Vibrio infection in aquaculture.
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