植物化学
多酚
抗氧化剂
化学
食品科学
类黄酮
传统医学
咖啡酸苯乙酯
萃取(化学)
非酒精性脂肪肝
咖啡酸
生物化学
脂肪肝
色谱法
医学
病理
疾病
作者
Zheng Li,Qiongyue Cao,Haoyu Chen,Junyi Yang,Zhihao Wang,Xiangquan Qu,Yuqin Yao,Zhengkun Zhou,Wei Zhang
标识
DOI:10.1021/acs.jafc.4c05125
摘要
Benth. (OSB) is a popular plant used for making "Shen tea" or "Java tea". It has been demonstrated with antioxidant, anti-inflammatory, and hepatoprotective activities. However, its potential beneficial effects and bioactive material basis for nonalcoholic fatty liver disease (NAFLD) has not been convincingly studied. In the present work, we conducted dual phytochemical/activity-guided extraction optimization and component fractionation of OSB, and evaluated its beneficial effects on NAFLD. Flavonoids and polyphenols (caffeic acid/protocatechuic acid derivatives) were determined as the dominant phytochemicals in OSB. The extraction process for these phytochemicals was optimized by using response surface methodology. Noticeably, flavonoids showed a stronger correlation with the antioxidant activities of OSB than polyphenols. Likewise, the flavonoid-rich fraction of OSB exerted antioxidant activities stronger than those of other fractions. As expected,
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