Statins as a Potential Treatment for Non-Alcoholic Fatty Liver Disease: Target Deconvolution using Protein-protein Interaction Network Analysis

脂肪肝 生物 基因 生物途径 他汀类 遗传学 疾病 医学 基因表达 生物化学 内科学
作者
Alireza Mahmoudi,Alexandra E. Butler,Alexander N. Orekhov,Tannaz Jamialahmadi,Amirhossein Sahebkar
出处
期刊:Current Medicinal Chemistry [Bentham Science]
卷期号:31
标识
DOI:10.2174/0929867331666230829164832
摘要

Background: The hallmark of non-alcoholic fatty liver disease (NAFLD) is aberrant buildup of triglycerides (TGs) in hepatocytes. Many genes promote NAFLD development. Using bioinformatics tools, we investigated the possible effect of statins on genes involved in NAFLD progression. Methods: Protein interactions of statins and NAFLD were searched in gene-drug and gene-disease databases. A Protein–Protein interaction (PPI) network was constructed to find hub genes and Molecular Complex Detection (MCODE) of NAFLD-related genes. Shared protein targets between protein targets of statins and NAFLD-associated genes were identified. Next, targets of each statin were assayed with all modular clusters in the MCODEs related to NAFLD. Biological process and pathway enrichment analysis for shared proteins was performed. Results: Screening protein targets for conventional statins and curated NAFLD-related genes identified 343 protein targets and 70 genes, respectively. A Venn diagram of NAFLD-related genes and protein targets of statins showed 24 shared proteins. The biological pathways on KEGG enrichment associated with the 24 shared protein sets were evaluated and included cytokine–cytokine receptor interaction, adipocytokine, PPAR, TNF and AMPK signaling pathways. Gene Ontology analysis showed major involvement in lipid metabolic process regulation and inflammatory response. PPI network analysis of 70 protein targets indicated 13 hub genes (PPARA, IL4, CAT, LEP, SREBF1, PRKCA, CYP2E1, NFE2L2, PTEN, NR1H4, ADIPOQ, GSTP1 and TGFB1). Comparing all seven statins with the three MCODE clusterings and 13 hub genes revealed that simvastatin as the most associated statin with NAFLD. Conclusions: Simvastatin has the most impact on NAFLD-related genes versus other statins.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
淡淡菠萝发布了新的文献求助10
1秒前
上官若男应助er采纳,获得10
2秒前
一静齐眉发布了新的文献求助10
3秒前
钰钰yuyu完成签到,获得积分10
4秒前
小马甲应助vg采纳,获得10
4秒前
hyq完成签到,获得积分10
5秒前
冰美式发布了新的文献求助10
5秒前
5秒前
憨憨发布了新的文献求助10
5秒前
vn完成签到,获得积分10
7秒前
7秒前
JS32发布了新的文献求助10
9秒前
10秒前
认真乐双完成签到,获得积分10
10秒前
汉堡包应助阿斯顿采纳,获得30
10秒前
11秒前
13秒前
day完成签到,获得积分10
13秒前
蛋壳柯发布了新的文献求助10
14秒前
cyxcr发布了新的文献求助10
14秒前
er完成签到,获得积分20
16秒前
18秒前
合适怡完成签到,获得积分10
18秒前
18秒前
可爱的函函应助37采纳,获得10
19秒前
蛋壳柯完成签到,获得积分10
21秒前
22秒前
研友_LX62KZ完成签到,获得积分10
23秒前
23秒前
24秒前
齐佳完成签到,获得积分10
24秒前
研友_LX62KZ发布了新的文献求助10
26秒前
27秒前
emilybei发布了新的文献求助10
28秒前
薰硝壤应助kkk556采纳,获得20
28秒前
march发布了新的文献求助10
29秒前
cym666666完成签到,获得积分10
29秒前
未央天完成签到 ,获得积分10
30秒前
半夏完成签到,获得积分10
30秒前
高分求助中
The Oxford Handbook of Social Cognition (Second Edition, 2024) 1050
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Chen Hansheng: China’s Last Romantic Revolutionary 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3140690
求助须知:如何正确求助?哪些是违规求助? 2791543
关于积分的说明 7799499
捐赠科研通 2447880
什么是DOI,文献DOI怎么找? 1302159
科研通“疑难数据库(出版商)”最低求助积分说明 626459
版权声明 601194