全基因组关联研究
单核苷酸多态性
腰围
遗传关联
医学
体质指数
遗传学
生物
内科学
基因型
基因
作者
Jian-Shiun Chiou,Chi Cheng,Wen Miin Liang,Chen-Hsing Chou,Chung Hsing Wang,Wei Lin,Mu-Lin Chiu,Wei-Chung Cheng,Cheng Wen Lin,Ting Lin,Chiu Chu Liao,Brian O'Sullivan,Chang Hai Tsai,Ying Lin,Fuu Jen Tsai
出处
期刊:BMC Medicine
[Springer Nature]
日期:2022-07-13
卷期号:20 (1)
被引量:3
标识
DOI:10.1186/s12916-022-02450-w
摘要
Height is an important anthropometric measurement and is associated with many health-related outcomes. Genome-wide association studies (GWASs) have identified hundreds of genetic loci associated with height, mainly in individuals of European ancestry.We performed genome-wide association analyses and replicated previously reported GWAS-determined single nucleotide polymorphisms (SNPs) in the Taiwanese Han population (Taiwan Biobank; n = 67,452). A genetic instrument composed of 251 SNPs was selected from our GWAS, based on height and replication results as the best-fit polygenic risk score (PRS), in accordance with the clumping and p-value threshold method. We also examined the association between genetically determined height (PRS251) and measured height (phenotype). We performed observational (phenotype) and genetic PRS251 association analyses of height and health-related outcomes.GWAS identified 6843 SNPs in 89 genomic regions with genome-wide significance, including 18 novel loci. These were the most strongly associated genetic loci (EFEMP1, DIS3L2, ZBTB38, LCORL, HMGA1, CS, and GDF5) previously reported to play a role in height. There was a positive association between PRS251 and measured height (p < 0.001). Of the 14 traits and 49 diseases analyzed, we observed significant associations of measured and genetically determined height with only eight traits (p < 0.05/[14 + 49]). Height was positively associated with body weight, waist circumference, and hip circumference but negatively associated with body mass index, waist-hip ratio, body fat, total cholesterol, and low-density lipoprotein cholesterol (p < 0.05/[14 + 49]).This study contributes to the understanding of the genetic features of height and health-related outcomes in individuals of Han Chinese ancestry in Taiwan.
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