151. INFLUENCE OF PERIOPERATIVE ANEMIA ON MORBIDITY AND MORTALITY OUTCOMES AFTER RADICAL ESOPHAGECTOMY

Abstract Objectives Methods Retrospective and analytical study of patients who underwent radical esophagectomy for esophageal cancer performed in our institution from 2015 to 2021. Several parameters related to anemia were measured: hemoglobin, ferritin, transferrin saturation and iron blood levels, as well as the need for perioperative blood transfusion. We analyzed, on the one hand, the incidence of complications in the immediate postoperative period. On the other hand, we assessed the results of overall survival and disease-free survival in relation to tumor disease. Results A total of 137 patients treated for esophageal neoplasia were included. The interventions performed were McKeown/Ivor-Lewis esophagectomy. Up to 106 (77,4%) patients received neoadjuvant therapy. Patients who required transfusion in the perioperative period (35 patients; 26%) had a significantly lower mean survival (33 vs. 53 months). In addition, they presented higher rates of postoperative complications as well as a lower 5-year overall survival (Log Rank; p = 0.004). Patients with preoperative hemoglobin levels below 12 g/dL had a significantly higher recurrence rate (21% vs. 7%; p < 0.05). The anemic status was improved after the implementation of a multimodal prehabilitation protocol (12.1 g/dL versus 13 g/dL). Conclusions Radical esophagectomy is associated with high morbidity and mortality. Minimally invasive surgery has improved intra and postoperative outcomes. Despite this, the risk of intraoperative bleeding is not negligible. Therefore, it is essential for the patient to be in an optimal clinical and analytical status. Multimodal prehabilitation could improve this status and the postoperative recovery. Studies with a larger number of patients and a longer follow-up will be necessary to evaluate the impact of this strategy.