Engineered extracellular vesicles containing endogenous retrovirus-like capsids—a glimpse into the future of gene therapy

Extracellular vesicles (EVs) are potential gene therapy platforms, yet their therapeutic use is hindered by low encapsulation efficiency and weak targeting specificity. A recent Nature Biomedical Engineering study reports the retrovirus-like EVs for efficient mRNA delivery to the CNS, showing considerable promise for systematic, targeted, and efficient gene therapy. Extracellular vesicles (EVs) are potential gene therapy platforms, yet their therapeutic use is hindered by low encapsulation efficiency and weak targeting specificity. A recent Nature Biomedical Engineering study reports the retrovirus-like EVs for efficient mRNA delivery to the CNS, showing considerable promise for systematic, targeted, and efficient gene therapy.