Multiscale Modeling of Bistability in the Yeast Polarity Circuit

极性(国际关系) 双稳态 生物系统 电池极性 颂歌 反应扩散系统 物理 统计物理学 非正面反馈 常微分方程 正面反馈 计算机科学 微分方程 化学 数学 数学分析 细胞 生物 量子力学 生物化学 工程类 电压 电气工程
作者
Siarhei Hladyshau,Kaiyun Guan,Nivedita Nivedita,Beverly Errede,Denis Tsygankov,Timothy C. Elston
出处
期刊:Cells [MDPI AG]
卷期号:13 (16): 1358-1358
标识
DOI:10.3390/cells13161358
摘要

Cell polarity refers to the asymmetric distribution of proteins and other molecules along a specified axis within a cell. Polarity establishment is the first step in many cellular processes. For example, directed growth or migration requires the formation of a cell front and back. In many cases, polarity occurs in the absence of spatial cues. That is, the cell undergoes symmetry breaking. Understanding the molecular mechanisms that allow cells to break symmetry and polarize requires computational models that span multiple spatial and temporal scales. Here, we apply a multiscale modeling approach to examine the polarity circuit of yeast. In addition to symmetry breaking, experiments revealed two key features of the yeast polarity circuit: bistability and rapid dismantling of the polarity site following a loss of signal. We used modeling based on ordinary differential equations (ODEs) to investigate mechanisms that generate these behaviors. Our analysis revealed that a model involving positive and negative feedback acting on different time scales captured both features. We then extend our ODE model into a coarse-grained reaction–diffusion equation (RDE) model to capture the spatial profiles of polarity factors. After establishing that the coarse-grained RDE model qualitatively captures key features of the polarity circuit, we expand it to more accurately capture the biochemical reactions involved in the system. We convert the expanded model to a particle-based model that resolves individual molecules and captures fluctuations that arise from the stochastic nature of biochemical reactions. Our models assume that negative regulation results from negative feedback. However, experimental observations do not rule out the possibility that negative regulation occurs through an incoherent feedforward loop. Therefore, we conclude by using our RDE model to suggest how negative feedback might be distinguished from incoherent feedforward regulation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
活泼山雁发布了新的文献求助10
刚刚
kelaibing发布了新的文献求助10
刚刚
1秒前
1秒前
2秒前
学术蝗虫发布了新的文献求助10
2秒前
3秒前
3秒前
华仔应助董竹君采纳,获得10
4秒前
cczy发布了新的文献求助10
4秒前
hygge完成签到 ,获得积分10
4秒前
5秒前
6秒前
BLock发布了新的文献求助10
7秒前
米花发布了新的文献求助10
7秒前
8秒前
8秒前
9秒前
哈哈哈发布了新的文献求助10
9秒前
Robin完成签到,获得积分20
9秒前
xin发布了新的文献求助10
10秒前
paopao发布了新的文献求助10
14秒前
干净的夜蓉完成签到,获得积分20
14秒前
14秒前
14秒前
吴雨木目完成签到 ,获得积分10
15秒前
鹿lu完成签到,获得积分10
15秒前
酷波er应助BLock采纳,获得10
16秒前
17秒前
领导范儿应助润润润采纳,获得10
17秒前
汀烟应助kelaibing采纳,获得10
18秒前
故里完成签到,获得积分10
19秒前
20秒前
20秒前
一一应助ran采纳,获得10
20秒前
俊逸沛菡发布了新的文献求助10
20秒前
20秒前
21秒前
buno应助科研通管家采纳,获得10
21秒前
烟花应助科研通管家采纳,获得10
21秒前
高分求助中
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
The Heath Anthology of American Literature: Early Nineteenth Century 1800 - 1865 Vol. B 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Machine Learning for Polymer Informatics 500
《关于整治突出dupin问题的实施意见》(厅字〔2019〕52号) 500
2024 Medicinal Chemistry Reviews 480
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3222562
求助须知:如何正确求助?哪些是违规求助? 2871242
关于积分的说明 8174624
捐赠科研通 2538263
什么是DOI,文献DOI怎么找? 1370390
科研通“疑难数据库(出版商)”最低求助积分说明 645793
邀请新用户注册赠送积分活动 619580