等几何分析
单克隆抗体
皮下注射
医学
抗体
数学
有限元法
免疫学
结构工程
工程类
内科学
作者
Mario de Lucio,Miguel Bures,Arezoo M. Ardekani,Pavlos Vlachos,Hector Gomez
标识
DOI:10.1016/j.cma.2020.113550
摘要
Abstract Subcutaneous injection for self-administration of biotherapeutics, such as monoclonal antibodies, has emerged as a fast-growing field in the pharmaceutical industry. Effective drug delivery in the subcutaneous tissue critically depends on the coupled mechanical and transport processes occurring in the tissue during and after the injection. The details of these processes, however, remain poorly understood; and this explains the growing interest in computational approaches. Notably, there are very few computational studies on subcutaneous injection into three-dimensional porous media that account for tissue deformability. Here, we leverage a poroelastic model to analyze the response of subcutaneous tissue under the flow of a pressurized fluid. We propose a computational method based on Isogeometric Analysis that exploits the global continuity of splines. Our model shows the importance of considering tissue deformation and permeability changes in order to obtain more realistic results in terms of fluid pressure and velocity, during and after the injection.
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