脚手架
再生(生物学)
肌腱
干细胞
再生医学
组织工程
细胞生物学
细胞分化
生物
解剖
生物医学工程
医学
生物化学
基因
作者
Hong Zhang,Mengfei Liu,Richun Liu,Weiliang Shen,Zi Yin,Xiao Chen
出处
期刊:Tissue Engineering Part B-reviews
[Mary Ann Liebert, Inc.]
日期:2018-05-04
卷期号:24 (6): 443-453
被引量:20
标识
DOI:10.1089/ten.teb.2018.0018
摘要
Tendon injuries are common musculoskeletal system disorders, but the tendons have poor regeneration ability. To address this issue, tendon tissue engineering provides potential strategies for future therapeutic treatment. Elements of the physical microenvironment, such as the mechanical force and surface topography, play a vital role in regulating stem cell fate, enhancing the differentiation efficiency of seed cells in tendon tissue engineering. Various inducible scaffolds have been widely explored for tendon regeneration, and scaffold-enhancing modifications have been extensively studied. In this review, we systematically summarize the effects of the physical microenvironment on stem cell differentiation and tendon regeneration; we also provide an overview of the inducible scaffolds for stem cell tenogenic differentiation. Finally, we suggest some potential scaffold-based therapies for tendon injuries, presenting an interesting perspective on tendon regenerative medicine.
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