心理学
凝视
重性抑郁障碍
眼动
心情
认知心理学
意识的神经相关物
扁桃形结构
神经科学
人工智能
认知
临床心理学
计算机科学
精神分析
作者
Rui Sun,Julia Fietz,Mira Erhart,Dorothee Poehlchen,Lara Henco,Tanja Brückl,Elisabeth B. Binder,Angelika Erhardt,Susanne Lucae,Norma C. Grandi,Tamara Namendorf,Immanuel Elbau,Laura Leuchs,Anna-Katharine Brem,Leonhard Schilbach,Sanja Ilić-Ćoćić,Julius Ziebula,Iven-Alex von Mücke-Heim,Yeho Kim,Julius C. Pape,Michael Czisch,Philipp G. Saemann,Victor I. Spoormaker
标识
DOI:10.1007/s00406-023-01608-8
摘要
Abstract Major depressive disorder (MDD) has been related to abnormal amygdala activity during emotional face processing. However, a recent large-scale study ( n = 28,638) found no such correlation, which is probably due to the low precision of fMRI measurements. To address this issue, we used simultaneous fMRI and eye-tracking measurements during a commonly employed emotional face recognition task. Eye-tracking provide high-precision data, which can be used to enrich and potentially stabilize fMRI readouts. With the behavioral response, we additionally divided the active task period into a task-related and a free-viewing phase to explore the gaze patterns of MDD patients and healthy controls (HC) and compare their respective neural correlates. Our analysis showed that a mood-congruency attentional bias could be detected in MDD compared to healthy controls during the free-viewing phase but without parallel amygdala disruption. Moreover, the neural correlates of gaze patterns reflected more prefrontal fMRI activity in the free-viewing than the task-related phase. Taken together, spontaneous emotional processing in free viewing might lead to a more pronounced mood-congruency bias in MDD, which indicates that combined fMRI with eye-tracking measurement could be beneficial for our understanding of the underlying psychopathology of MDD in different emotional processing phases. Trial Registration : The BeCOME study is registered on ClinicalTrials (gov: NCT03984084) by the Max Planck Institute of Psychiatry in Munich, Germany.
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