分子印迹聚合物
检出限
色谱法
高效液相色谱法
固相萃取
整体
萃取(化学)
联苯胺
移液管
吸附
分子印迹
化学
聚合
聚合物
有机化学
选择性
物理化学
催化作用
作者
Yang Liu,Xueping Dang,Shicheng Zhang,Yuling Hu,Huaixia Chen
标识
DOI:10.1016/j.fpsl.2023.101029
摘要
Some food contact materials (FCMs) may contain aromatic amines (AAs), which would migrate to food and pose a serious threat to human health. An extraction and determination method for AAs was established using pipette tip solid-phase extraction (PTSPE) combined with high performance liquid chromatography-photodiode array detector (HPLC-PAD). The PTSPE was based on molecularly imprinted polymer (MIP) monolith, which was synthesized in situ polymerization using benzidine as template molecule and 4-vinylpyridine as functional monomer. It was applied for selective extraction of six AAs from FCMs, including benzidine, 3,3′-dimethyl-4,4′-diaminodiphenylmethane, 2-methoxy-5-methylaniline, 3,3′-dimethoxybenzidine, 4,4′-methylenedianiline and 4-aminobiphenyl. The MIP monolith showed highly specific recognition and good adsorption ability for the six AAs, the imprinting factor for 4,4′-methylenedianiline can reach 4.29 and the adsorption capacity for 4-aminobiphenyl can reach 112.3 mg g−1. The linear range of the determination method for the six AAs was 0.60–500 µg kg−1 (R2>0.997), the limits of quantitation was 0.60–4.50 µg kg−1 and the limits of detection (S/N = 3) was 0.20–1.50 µg kg−1. The MIP-PTSPE-HPLC-PAD method was applied for the migration detection of six AAs from polyamide kitchenware and the absolute recovery were 81.7–110.9%.
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