双孢蘑菇
葡聚糖
下调和上调
蛋黄
化学
脂质代谢
自噬
葡萄聚糖
油红O
食品科学
生物
生物化学
脂肪生成
脂肪组织
基因
细胞凋亡
蘑菇
作者
Xiu-Min Li,Yu Xue,Liang Pang,Bo Len,Zhichao Lin,Jiafu Huang,Zhaoshui Shangguan,Yutian Pan
标识
DOI:10.1016/j.ijbiomac.2018.12.122
摘要
β-(1,4)-d-Glucan with (1,2) and (1,6)-linked branches (short for β-glucan), extracted from Agaricus bisporus (Lange) Sing, had significant anti-obesity and lowering-fat effect. FITC-β-glucan was absorbed by adipocytes of zebrafish larvae when stained by Nile Red. β-Glucan decreased the adiposity mass, reduced the expression of ppar g, mtp, L-fabp, ifabp in ISH, which was coincident as the results of RT-PCT. β-Glucan lowered the level of C/EBP α, c SREBP1, LXR α, PPAR γ by WB analysis, which were accompanied by an increase level in LC3 II/LC3 I and a decline level in p62 in dose-dependent manner. This study explored the effect and mechanisms of Agaricus bisporus derived-β-glucan to regulate lipid metabolism and prevent lipid deposits, and provided the experimental data for its use in diet food and food addictive.
科研通智能强力驱动
Strongly Powered by AbleSci AI