Dietary flaxseed oil induces production of adiponectin in visceral fat and prevents obesity in mice

脂联素 脂肪组织 内分泌学 内科学 白色脂肪组织 玉米油 脂肪酸 化学 产热 肥胖 生物 胰岛素抵抗 医学 生物化学
作者
Midori Seike,Hitoshi Ashida,Yoko Yamashita
出处
期刊:Nutrition Research [Elsevier BV]
卷期号:121: 16-27 被引量:4
标识
DOI:10.1016/j.nutres.2023.11.004
摘要

Induction of obesity by dietary fats and oils differs according to the type of fat. Adiponectin is believed to be related to obesity prevention. We hypothesized that flaxseed oil is important for prevention of obesity and production of adiponectin. To clarify this hypothesis, we investigated the relationship between obesity and different fat sources in mice fed diets with six types of fat and oils. C57BL/6J mice were given a control diet containing 5% corn oil or a high-fat diet containing 20% of either lard, palm oil, rapeseed oil, oleate-rich safflower oil, corn oil, or flaxseed oil for 14 weeks. In another experiment, mice were given a control diet and rosiglitazone (10 mg/kg body weight) by oral gavage for one week. At the end of study, plasma adiponectin and expression of fatty acid metabolism-related factors in white and brown adipose tissue and the liver were measured. Dietary flaxseed oil, which is rich in α-linolenic acid, did not induce obesity. Flaxseed oil resulted in increased β-oxidation-related factors in epididymal white adipose tissue, decreased fatty acid synthesis-related factors in the liver, and thermogenesis-related factor in brown adipose tissue following increase of plasma adiponectin. The results suggested that increase in plasma adiponectin after intake of flaxseed oil may be due to altered expression of AdipoQ and peroxisome proliferator-activated receptor γ in epididymal white adipose tissue. Flaxseed oil increased expression of adiponectin in visceral fat and regulated obesity-controlling fatty acid metabolism-related factors in white adipose tissue and liver, and thermogenesis-related factor in brown adipose tissue.
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