时辰疗法(睡眠期)
昼夜节律
药品
药理学
褪黑素
医学
生物钟
生物
内科学
作者
Françis Lévi,Alper Okyar,Éva Hadadi,Pasquale F. Innominato,Annabelle Ballesta
出处
期刊:Annual Review of Pharmacology and Toxicology
[Annual Reviews]
日期:2023-09-19
卷期号:64 (1): 89-114
被引量:18
标识
DOI:10.1146/annurev-pharmtox-051920-095416
摘要
Today's challenge for precision medicine involves the integration of the impact of molecular clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy. Meaningful improvements of tolerability and/or efficacy of medications through proper administration timing have been confirmed over the past decade for immunotherapy and chemotherapy against cancer, as well as for commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, and neurological conditions. Experimental and human studies have recently revealed sexually dimorphic circadian drug responses. Dedicated randomized clinical trials should now aim to issue personalized circadian timing recommendations for daily medical practice, integrating innovative technologies for remote longitudinal monitoring of circadian metrics, statistical prediction of molecular clock function from single-timepoint biopsies, and multiscale biorhythmic mathematical modelling. Importantly, chronofit patients with a robust circadian function, who would benefit most from personalized chronotherapy, need to be identified. Conversely, nonchronofit patients could benefit from the emerging pharmacological class of chronobiotics targeting the circadian clock.
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