挤压
熔融沉积模型
差示扫描量热法
聚乳酸
材料科学
溶解
3D打印
沉积(地质)
喷嘴
3d打印
化学工程
聚合物
复合材料
生物医学工程
机械工程
古生物学
沉积物
工程类
医学
物理
生物
热力学
作者
Peilun Zhang,Jinghan Li,Eman A. Ashour,Sooyeon Chung,Honghe Wang,Sateesh Kumar Vemula,Michael A. Repka
标识
DOI:10.1016/j.ijpharm.2024.123905
摘要
The study aims to fabricate extended release (ER) tablets using a dual-nozzle fused deposition modeling (FDM) three-dimensional (3D) printing technology based on hot melt extrusion (HME), using caffeine as the model compound. Three different ER tablets were developed, which obtained "delayed-release", "rapid-sustained release", and "release-lag-release" properties. Each type of tablet was printed with two different formulations. A novel printing method was employed in this study, which is to push the HME filament from behind with polylactic acid (PLA) to prevent sample damage by gears during the printing process. Powder X-ray diffractometry (PXRD) and differential scanning calorimetry (DSC) results showed that caffeine was predominately amorphous in the final tablets. The dissolution of 3D printed tablets was assessed using a USP-II dissolution apparatus. ER tablets containing PVA dissolved faster than those developed with Kollicoat IR. Overall, this study revealed that ER tablets were successfully manufactured through HME paired with dual-nozzle FDM 3D printing and demonstrated the power of 3D printing in developing multi-layer tablets with complex structures.
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