单克隆抗体
肝素
抗体
血小板因子4
免疫学
多克隆抗体
医学
血小板
肝素诱导血小板减少症
内科学
作者
Adam Kanack,Antonios Bayas,Gemlyn George,Mouhamed Yazan Abou-Ismail,Bandana Singh,Mindy Kohlhagen,Noah Splinter,Monika Christ,Markus Naumann,Karen A Moser,Kristi J. Smock,Alison Grazioli,Renren Wen,Demin Wang,David L Murray,Anand Padmanabhan
出处
期刊:Blood
[American Society of Hematology]
日期:2022-05-13
卷期号:140 (1): 73-77
被引量:5
标识
DOI:10.1182/blood.2021014588
摘要
Kanack and colleagues analyze anti-platelet factor 4 antibodies from 5 patients with vaccine-induced thrombotic thrombocytopenia (VITT) secondary to COVID-19 adenoviral vaccination and antibodies from patients with spontaneous heparin-induced thrombocytopenia (HIT) and classical HIT. VITT antibodies are monoclonal or oligoclonal, similar to spontaneous HIT, whereas classical HIT antibodies are polyclonal. Heparin inhibits antibody-induced platelet activation in VITT, suggesting that heparin should be considered for the treatment of VITT.
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