Genetic polymorphism of cytochrome P450 2C19 in Mexican Americans: A cross-ethnic comparative study

CYP2C19型 民族 置信区间 基因型 等位基因 人口学 等位基因频率 遗传学 医学 内科学 生物 基因 社会学 人类学
作者
Huai Rong Luo,Russell E. Poland,Keh Ming Lin,Yu‐Jui Yvonne Wan
出处
期刊:Clinical Pharmacology & Therapeutics [Wiley]
卷期号:80 (1): 33-40 被引量:104
标识
DOI:10.1016/j.clpt.2006.03.003
摘要

Objectives Our objectives were to investigate cytochrome P450 (CYP) 2C19 polymorphism in Mexican Americans and compare the findings with those in 4 other ethnic groups. Methods The CYP2C19 genotype (n = 346) and S-mephenytoin hydroxylation phenotype (n = 220) were studied in a Mexican American population from Los Angeles County. Another 4 ethnic groups, African Americans (n = 236), whites (n = 273), East Asians (n = 161), and Southeast Asians (n = 80), were also recruited from Los Angeles County and genotyped and phenotyped for CYP2C19. Results The frequencies of CYP2C19*2 and *3 were 9.7% and 0.1%, respectively, in Mexican Americans, which were lower than those of the other 4 ethnic groups, ranging from 12.7% to 31.2% and 0.8% to 9.6%, respectively (P ≤ .035). Seven Mexican American subjects were phenotyped as poor metabolizers. Thus the frequency of poor metabolizers in the Mexican American subjects was 3.2% (95% confidence interval, 0%-11.9%), which is similar to that of African Americans (5.4%) and whites (5.0%) and lower than that of East Asians (16.7%; P < .001) and Southeast Asians (23.9%; P < .001). Of the 7 poor metabolizers who were also genotyped, 2 were homozygous for the CYP2C19*2 alleles. CYP2C19*4, *5, *6, *7, and *8 were studied and did not account for the unexplained finding. The number of functional alleles among the extensive metabolizers correlated with the phenotype, suggesting a gene-dosage effect in Mexican Americans. Conclusions This is the first study to investigate CYP2C19 polymorphism in Mexican Americans. The frequencies of the CYP2C19*2 and *3 alleles in Mexican Americans were found to be significantly lower than in other ethnic groups. This genotypic pattern might be responsible for the lower rate of poor metabolizers in Mexican Americans compared with other ethnic groups. Clinical Pharmacology & Therapeutics (2006) 80, 33–40; doi:10.1016/j.clpt.2006.03.003
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
想抱完成签到,获得积分10
1秒前
Mae完成签到 ,获得积分10
1秒前
读博读博完成签到,获得积分10
1秒前
针尖上的王子完成签到,获得积分10
2秒前
酷炫魂幽完成签到,获得积分10
2秒前
拼搏尔风完成签到,获得积分10
4秒前
秋水揽星河完成签到,获得积分10
5秒前
Yan123456完成签到,获得积分10
5秒前
CipherSage应助李半斤采纳,获得10
5秒前
轻松元绿完成签到 ,获得积分10
9秒前
tingalan完成签到,获得积分10
9秒前
圣晟胜完成签到,获得积分10
9秒前
平淡寻菡完成签到,获得积分10
10秒前
W.X.完成签到,获得积分10
11秒前
今后应助西河采纳,获得10
11秒前
赘婿应助TheQ采纳,获得10
12秒前
pokemeow完成签到,获得积分10
12秒前
坚强的寒风完成签到,获得积分10
13秒前
ll完成签到,获得积分10
13秒前
14秒前
ice7完成签到,获得积分10
14秒前
勤恳的嚓茶完成签到,获得积分10
15秒前
温暖宛筠完成签到,获得积分10
15秒前
落后冬云完成签到 ,获得积分10
15秒前
AteeqBaloch完成签到,获得积分10
15秒前
吉吉完成签到,获得积分10
16秒前
Viikey完成签到,获得积分0
16秒前
科研通AI2S应助Zzz采纳,获得10
16秒前
高晓澍完成签到,获得积分10
16秒前
Emily完成签到,获得积分10
17秒前
英俊亦巧完成签到,获得积分10
17秒前
17秒前
李半斤完成签到,获得积分10
17秒前
奋斗的大白菜完成签到,获得积分10
17秒前
18秒前
halona完成签到,获得积分10
19秒前
19秒前
胡呵呵完成签到 ,获得积分20
20秒前
忧郁友绿完成签到,获得积分10
21秒前
体贴向珊完成签到,获得积分10
22秒前
高分求助中
Evolution 10000
CANCER DISCOVERY癌症研究的新前沿:中国科研领军人物的创新构想 中国专刊 500
Distribution Dependent Stochastic Differential Equations 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
Die Gottesanbeterin: Mantis religiosa: 656 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3158687
求助须知:如何正确求助?哪些是违规求助? 2809923
关于积分的说明 7884302
捐赠科研通 2468638
什么是DOI,文献DOI怎么找? 1314374
科研通“疑难数据库(出版商)”最低求助积分说明 630601
版权声明 602012