肌球蛋白
基因亚型
骨骼肌
细胞生物学
生物
基因表达
基因表达调控
基因
MYH7
遗传学
肌球蛋白轻链激酶
内分泌学
作者
Kenneth M. Baldwin,Fadia Haddad
出处
期刊:PubMed
日期:2002-11-01
卷期号:81 (11 Suppl): S40-51
被引量:165
标识
DOI:10.1097/01.phm.0000029723.36419.0d
摘要
The goal of this article is to examine our current understanding of the chain of events known to be involved in the adaptive process whereby specific genes and their protein products undergo altered expression; specifically, skeletal muscle adaptation in response to altered loading states will be discussed, with a special focus on the regulation of the contractile protein, myosin heavy chain gene expression. This protein, which is both an important structural and regulatory protein comprising the contractile apparatus, can be expressed as different isoforms, thereby having an impact on the functional diversity of the muscle. Because the regulation of the myosin gene family is under the control of a complex set of processes including, but not limited to, activity, hormonal, and metabolic factors, this protein will serve as a cellular "marker" for studies of muscle plasticity in response to various mechanical perturbations in which the quantity and type of myosin isoform, along with other important cellular proteins, are altered in expression.
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