败血症
脂多糖
炎症
一氧化氮
肿瘤坏死因子α
NF-κB
体内
腹膜腔
巨噬细胞
分泌物
药理学
白细胞介素6
促炎细胞因子
医学
免疫学
癌症研究
生物
内科学
体外
生物化学
生物技术
解剖
作者
Guodong He,Xu Zhang,Yanhua Chen,Jing Chen,Li Li,Yubo Xie
标识
DOI:10.1016/j.biopha.2017.03.095
摘要
Sepsis, a clinical syndrome occurring in patients following infection or injury, is a leading cause of mortality worldwide. It involves uncontrolled inflammatory response resulting in multi-organ failure and even death. Isoalantolactone (IAL), a sesquiterpene lactone, is known for its anti-cancer effects. Nevertheless, little is known about the anti-inflammatory effects of IAL, and the role of IAL in sepsis is unclear. In this study, we demonstrated that IAL decreased lipopolysaccharide (LPS)-mediated production of nitric oxide, PEG2 and cytokines (IL-6, TNF-α) in peritoneal macrophages and RAW 264.7 macrophages. Moreover, molecular mechanism studies indicated that IAL plays an anti-inflammatory role by inhibiting LPS-induced activation of NF-κB pathway in peritoneal macrophages. In vivo, IAL reduced the secretion of IL-6 and TNF-α in serum, and increased the survival rate of mice with LPS-induced sepsis. In addition, IAL attenuated the activation of NF-κB pathway in liver. Taken together, our data suggest that IAL may represent a potentially new drug candidate for the treatment of sepsis.
科研通智能强力驱动
Strongly Powered by AbleSci AI