The immunology of PF4 polyanion interactions

免疫学 血液学 计算生物学 医学 化学 生物
作者
Anh T. P. Ngo,Veronica Bochenek,Kandace Gollomp
出处
期刊:Current Opinion in Hematology [Ovid Technologies (Wolters Kluwer)]
卷期号:30 (6): 219-229 被引量:3
标识
DOI:10.1097/moh.0000000000000782
摘要

Purpose of review Platelet factor 4 (PF4, CXCL4), the most abundant α-granule platelet-specific chemokine, forms tetramers with an equatorial ring of high positive charge that bind to a wide range of polyanions, after which it changes conformation to expose antigenic epitopes. Antibodies directed against PF4 not only help to clear infection but can also lead to the development of thrombotic disorders such as heparin-induced thrombocytopenia (HIT) and vaccine-induced thrombocytopenia and thrombosis (VITT). This review will outline the different mechanisms through which PF4 engagement with polyanions combats infection but also contributes to the pathogenesis of inflammatory and thrombotic disease states. Recent findings Recent work has shown that PF4 binding to microbial polyanions may improve outcomes in infection by enhancing leukocyte-bacterial binding, tethering pathogens to neutrophil extracellular traps (NETs), decreasing the thrombotic potential of NET DNA, and modulating viral infectivity. However, PF4 binding to nucleic acids may enhance their recognition by innate immune receptors, leading to autoinflammation. Lastly, while HIT is induced by platelet activating antibodies that bind to PF4/polyanion complexes, VITT, which occurs in a small subset of patients treated with COVID-19 adenovirus vector vaccines, is characterized by prothrombotic antibodies that bind to PF4 alone. Summary Investigating the complex interplay of PF4 and polyanions may provide insights relevant to the treatment of infectious disease while also improving our understanding of the pathogenesis of thrombotic disorders driven by anti-PF4/polyanion and anti-PF4 antibodies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
枯木逢春发布了新的文献求助10
1秒前
无敌最俊朗应助ZMY采纳,获得50
1秒前
LBJ23发布了新的文献求助10
2秒前
2秒前
juanjua发布了新的文献求助10
2秒前
所所应助Hao采纳,获得10
2秒前
京京京发布了新的文献求助10
2秒前
3秒前
悠悠u发布了新的文献求助50
3秒前
勤恳的果汁完成签到,获得积分10
3秒前
3秒前
陈追命发布了新的文献求助10
4秒前
科研通AI2S应助咕噜采纳,获得10
4秒前
5秒前
6秒前
6秒前
6秒前
mimi发布了新的文献求助50
6秒前
Phosphene应助爱岛观子采纳,获得10
6秒前
不安的傲柏完成签到,获得积分10
7秒前
PFSYRGZ发布了新的文献求助10
7秒前
9527发布了新的文献求助30
8秒前
三十七度医完成签到,获得积分10
9秒前
9秒前
ares-gxd发布了新的文献求助10
9秒前
9464完成签到 ,获得积分10
9秒前
10秒前
chengfeng完成签到,获得积分20
10秒前
Joanna发布了新的文献求助10
11秒前
木木完成签到,获得积分10
11秒前
sniffgo发布了新的文献求助10
12秒前
旺崽完成签到,获得积分20
12秒前
淡淡邑完成签到,获得积分10
13秒前
13秒前
木木发布了新的文献求助10
14秒前
善学以致用应助xiaoxin采纳,获得10
14秒前
万能图书馆应助山青水秀采纳,获得10
15秒前
dola完成签到,获得积分10
15秒前
Orange应助bbow采纳,获得10
16秒前
高分求助中
Sustainability in Tides Chemistry 2000
Microlepidoptera Palaearctica, Volumes 1 and 3 - 13 (12-Volume Set) [German] 1122
Дружба 友好报 (1957-1958) 1000
The Data Economy: Tools and Applications 1000
Mantiden - Faszinierende Lauerjäger – Buch gebraucht kaufen 700
PraxisRatgeber Mantiden., faszinierende Lauerjäger. – Buch gebraucht kaufe 700
A Dissection Guide & Atlas to the Rabbit 600
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3101245
求助须知:如何正确求助?哪些是违规求助? 2752689
关于积分的说明 7620005
捐赠科研通 2404773
什么是DOI,文献DOI怎么找? 1275998
科研通“疑难数据库(出版商)”最低求助积分说明 616673
版权声明 599058