CD14型
脂多糖结合蛋白
脂多糖
巨噬细胞
化学
细胞生物学
抗体
免疫学
体外
生物
生物化学
受体
作者
Peter S. Tobias,Richard J. Ulevitch
出处
期刊:Immunobiology
[Elsevier]
日期:1993-04-01
卷期号:187 (3-5): 227-232
被引量:165
标识
DOI:10.1016/s0171-2985(11)80341-4
摘要
The activation of monocytes, macrophages, and neutrophils by lipopolysaccharides (LPS) involves a serum protein, LPS binding protein (LBP), and a membrane protein, CD14. Evidence to date suggests a pathway in which serum LPS first binds to LBP. The LPS-LBP complexes then interact with CD14, leading to cellular activation. This scheme is supported by experiments in which either LBP or CD14 are blocked by antibodies as well as experiments in which LBP is added to serum free media and CD14 is expressed on cells which normally lack CD14. Discovery of this pathway suggests novel approaches to anti-LPS therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI