医学
胆囊切除术
肠道菌群
胆结石
失调
胆汁酸
脂肪肝
肝肠循环
胃肠病学
新陈代谢
代谢综合征
内科学
疾病
免疫学
肥胖
作者
Mariana Amaral Raposo,Emília Oliveira,Andrey Santos,Dioze Guadagnini,Haquima El Mourabit,Chantal Housset,Sara Lemoinne,Mário J.A. Saad
标识
DOI:10.1016/j.clinre.2024.102370
摘要
Cholecystectomy is considered as a safe procedure to treat patients with gallstones. However, epidemiological studies highlighted an association between cholecystectomy and metabolic disorders, such as type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease (MASLD), independently of the gallstone disease. Following cholecystectomy, bile acids flow directly from the liver into the intestine, leading to changes in the entero-hepatic circulation of bile acids and their metabolism. The changes in bile acids metabolism impact the gut microbiota. Therefore, cholecystectomized patients display gut dysbiosis characterized by a reduced diversity, a loss of bacteria producing short-chain fatty acids and an increase in pro-inflammatory bacteria. Alterations of both bile acids metabolism and gut microbiota occurring after cholecystectomy can promote the development of metabolic disorders. In this review, we discuss the impact of cholecystectomy on bile acids and gut microbiota and its consequences on metabolic functions.
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