Toxic vascular effects of polystyrene microplastic exposure

粪便 微塑料 毒性 钙化 生理学 亚临床感染 摄入 病理 胸主动脉 生物 主动脉 医学 胃肠病学 内科学 微生物学 生态学
作者
Jianlong Yan,Yanbin Pan,Junbo He,Xinli Pang,Wenming Shao,Caiping Wang,Rongning Wang,Yaqiong He,Min Zhang,Juheng Ye,Chaolan Lin,Lin Feng,Yongshun Wang,Tangzhiming Li,Yu Lan,Yanbin Guo,Minxian Wang,Mengting Sun,Gong Yun,Mingpei Yuan,Da Yin,Xin Sun,Shaohong Dong
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:905: 167215-167215 被引量:20
标识
DOI:10.1016/j.scitotenv.2023.167215
摘要

Polystyrene microplastics (PSMPs) are some of the most common microplastic components, and the resulting pollution has become a global problem. Extensive studies have been conducted on the toxic effects of PSMPs on the heart, lungs, liver, kidneys, nerves, intestines and other tissues. However, the impact of PSMPs on vascular toxicity is poorly understood at present. The aim of this study was to reveal the vascular toxicity of microplastics (MPs). Patients were assigned to a calcification group (25 patients) or a non-calcification group (22 patients) based on the presence or absence of calcification in the thoracic aorta wall. We detected 7 polymer types in human feces. Patients with vascular calcification (VC) had higher levels of total MPs, polypropylene (PP) and polystyrene (PS) in feces than patients without VC. The thoracic aortic calcification score was significantly positively correlated with the total MP abundance (Spearman r = 0.8109, p < 0.0001), PP (Spearman r = 0.7211, p = 0.0160) and PS (Spearman r = 0.6523, p = 0.0471) in feces. We then explored the effects of PSMP exposure on normal and vitamin D3 + nicotine (VDN)-treated rats. PSMP exposure induced mild VC in normal rats and aggravated VC in VDN-treated rats. PSMP exposure disturbed the gut microbiota, causing Proteobacteria and Escherichia_Shigella to be the dominant phylum and genus, respectively. It also induced intestinal inflammatory responses in normal rats, aggravated intestinal inflammation in VDN-treated rats, impaired the intestinal mucosal barrier, and increased intestinal permeability. This study provides a theoretical basis for the risk assessment of MP-induced cardiovascular disease.
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