Toxic vascular effects of polystyrene microplastic exposure

粪便 微塑料 毒性 钙化 生理学 亚临床感染 摄入 病理 胸主动脉 生物 主动脉 医学 胃肠病学 内科学 微生物学 生态学
作者
Jianlong Yan,Yanbin Pan,Junbo He,Xinli Pang,Wenming Shao,Caiping Wang,Rongning Wang,Yaqiong He,Min Zhang,Juheng Ye,Chaolan Lin,Lin Feng,Yongshun Wang,Tangzhiming Li,Yu Lan,Yanbin Guo,Minxian Wang,Mengting Sun,Gong Yun,Mingpei Yuan,Da Yin,Xin Sun,Shaohong Dong
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:905: 167215-167215 被引量:20
标识
DOI:10.1016/j.scitotenv.2023.167215
摘要

Polystyrene microplastics (PSMPs) are some of the most common microplastic components, and the resulting pollution has become a global problem. Extensive studies have been conducted on the toxic effects of PSMPs on the heart, lungs, liver, kidneys, nerves, intestines and other tissues. However, the impact of PSMPs on vascular toxicity is poorly understood at present. The aim of this study was to reveal the vascular toxicity of microplastics (MPs). Patients were assigned to a calcification group (25 patients) or a non-calcification group (22 patients) based on the presence or absence of calcification in the thoracic aorta wall. We detected 7 polymer types in human feces. Patients with vascular calcification (VC) had higher levels of total MPs, polypropylene (PP) and polystyrene (PS) in feces than patients without VC. The thoracic aortic calcification score was significantly positively correlated with the total MP abundance (Spearman r = 0.8109, p < 0.0001), PP (Spearman r = 0.7211, p = 0.0160) and PS (Spearman r = 0.6523, p = 0.0471) in feces. We then explored the effects of PSMP exposure on normal and vitamin D3 + nicotine (VDN)-treated rats. PSMP exposure induced mild VC in normal rats and aggravated VC in VDN-treated rats. PSMP exposure disturbed the gut microbiota, causing Proteobacteria and Escherichia_Shigella to be the dominant phylum and genus, respectively. It also induced intestinal inflammatory responses in normal rats, aggravated intestinal inflammation in VDN-treated rats, impaired the intestinal mucosal barrier, and increased intestinal permeability. This study provides a theoretical basis for the risk assessment of MP-induced cardiovascular disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科目三应助浅斟低唱采纳,获得10
1秒前
CucRuotThua完成签到,获得积分10
1秒前
1秒前
温梦花雨完成签到 ,获得积分10
2秒前
3秒前
长安心动明月完成签到 ,获得积分10
4秒前
lgy发布了新的文献求助10
6秒前
尹小青发布了新的文献求助10
9秒前
喵喵7完成签到 ,获得积分10
10秒前
细雨带风吹完成签到,获得积分10
10秒前
12秒前
stop here完成签到,获得积分10
13秒前
英姑应助浅斟低唱采纳,获得10
17秒前
111完成签到 ,获得积分10
17秒前
20秒前
阿景发布了新的文献求助10
22秒前
24秒前
25秒前
baling发布了新的文献求助10
25秒前
研友_8y2o0L发布了新的文献求助10
27秒前
浅斟低唱发布了新的文献求助10
30秒前
取法乎上完成签到 ,获得积分10
30秒前
万能图书馆应助研友_8y2o0L采纳,获得10
31秒前
冬月完成签到,获得积分10
32秒前
张秋实完成签到,获得积分10
35秒前
wzx完成签到,获得积分10
38秒前
想啊想发布了新的文献求助20
38秒前
40秒前
夏至完成签到,获得积分10
40秒前
科研通AI5应助baling采纳,获得10
41秒前
41秒前
you完成签到,获得积分10
42秒前
英俊的铭应助秋石采纳,获得10
44秒前
小蘑菇应助浅斟低唱采纳,获得10
45秒前
Wu发布了新的文献求助10
45秒前
xixi789完成签到,获得积分10
49秒前
hyq完成签到,获得积分10
51秒前
壮观映波完成签到,获得积分10
53秒前
壮观映波发布了新的文献求助20
57秒前
三张发布了新的文献求助10
57秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Neuromuscular and Electrodiagnostic Medicine Board Review 1000
こんなに痛いのにどうして「なんでもない」と医者にいわれてしまうのでしょうか 510
The First Nuclear Era: The Life and Times of a Technological Fixer 500
Unusual formation of 4-diazo-3-nitriminopyrazoles upon acid nitration of pyrazolo[3,4-d][1,2,3]triazoles 500
岡本唐貴自伝的回想画集 500
Distinct Aggregation Behaviors and Rheological Responses of Two Terminally Functionalized Polyisoprenes with Different Quadruple Hydrogen Bonding Motifs 450
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3671635
求助须知:如何正确求助?哪些是违规求助? 3228335
关于积分的说明 9779690
捐赠科研通 2938645
什么是DOI,文献DOI怎么找? 1610206
邀请新用户注册赠送积分活动 760547
科研通“疑难数据库(出版商)”最低求助积分说明 736093