Silver-Catalyzed Dibromotrifluoromethoxylation of Terminal Alkynes

A silver-catalyzed dibromotrifluoromethoxylation of terminal alkynes has been reported, which provides the corresponding 1,1-dibromo-2-(trifluoromethoxy)alkenes in good yields and high regioselectivity under mild reaction conditions. The reaction exhibits a broad substrate scope and applies to late-stage trifluoromethoxylation of complex small molecules. Moreover, the products can be further modified, which provides a convenient method for the synthesis of compounds containing the OCF3 group.