胶束
叶酸受体
泊洛沙姆
阿霉素
化学
药物输送
叶酸
细胞培养
药理学
靶向给药
生物物理学
癌细胞
生物化学
癌症
化疗
生物
医学
有机化学
水溶液
内科学
聚合物
遗传学
共聚物
作者
Mohamed A. Elkhodiry,Ghaleb A. Husseini,Diana Velluto
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2016-08-24
卷期号:16 (10): 1275-1280
被引量:16
标识
DOI:10.2174/1871520616666160219161600
摘要
In this paper, we report on a potential cancer drug delivery system that utilizes the ligand targeting of the folate receptor. Our drug delivery system consists of Pluronic-P105 micelles, targeted with folic acid moieties. A melanoma folate positive (FR+) (B16-F10), and a fibroblast folate negative (FR-) (NIH-3T3) cell lines are used to compare the cellular accumulation of a chemotherapeutic drug (Doxorubicin) when the delivery is mediated by folated Pluronic P105 micelles. In order to obtain a proper comparison, we corrected for the quenching of Doxorubicin by folic acid molecules and illustrated the significant effect of quenching on the analysis of similar systems. Results show an 80% increase in the accumulation of the antineoplastic agent in the FR+ cell line, when compared to the FR- cell line, thus providing evidence that the efficacy of Pluronic micelles, as drug delivery vehicles, can be enhanced via folic acid targeting. Keywords: Doxorubicin, micelles, folate, active targeting, quenching, B16-F10, melanoma.
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