化学
磺酰
烷基
酯交换
烷氧基
有机化学
溶剂
催化作用
酒
微波加热
配体(生物化学)
组合化学
药物化学
微波食品加热
受体
生物化学
物理
量子力学
作者
Rebecka Isaksson,Ilze Kumpiņa,Mats Larhed,Johan Wannberg
标识
DOI:10.1016/j.tetlet.2016.02.071
摘要
A fast and convenient method for the alkoxy exchange of sulfonyl carbamates by simply heating in a chosen alkyl alcohol is described. No catalysts or additives are required. Microwave heating at 100–120 °C for 20–60 min resulted in good to excellent yields (53–93%) of alkyl (arylsulfonyl)carbamates where the alkyl part originates from the alcohol solvent. The developed protocol was applied to the synthesis of an angiotensin II type 2 receptor (AT2R) ligand.
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