ASYMMETRIC HYPERVALENT IODINE CATALYSIS

As the global issues of environment, energy, and natural resource scarcity increase, the development of environmentally friendly and efficient catalytic methodologies of organic synthesis is strongly demanded the sustainable advancement of material civilization. For this purpose, the use of toxic heavy metals and precious transition metals as reactants and/or catalysts should be avoided as much as possible, especially, in the synthesis of medicinal and pharmaceutical products. Over the past decades, hypervalent iodines have been the focus of great attention due to their mild and chemoselective oxidizing properties and their environmentally benign characteristics in contrast to toxic metal oxidants. In addition, the development of chiral hypervalent iodine-catalyzed enantioselective oxidative transformations is one of the most challenging and rewarding fields in asymmetric organocatalysis. This chapter describes the recent progress on the development of enantioselective hypervalent organoiodine catalysis for oxidative coupling reactions.