黄曲霉毒素
槟榔碱
致癌物
槟榔
消化道
食品科学
人类健康
毒性
生物
毒理
医学
环境卫生
生物化学
螺母
内科学
受体
毒蕈碱乙酰胆碱受体
结构工程
工程类
作者
Dandan Kong,Gaofeng Wang,Jing Wang,Mengyue Guo,Zia Ul Haq Khan,Yifei Guo,Wei Gu,Yonggui Ma,Ming Sui,Jinping Li,Meihua Yang
标识
DOI:10.1016/j.foodres.2022.112012
摘要
Contemporarily, there has been a growing consumption rate of areca nut (AN) products worldwide, despite the fact that both fresh and processed AN contain various hazardous ingredients, including toxic alkaloids and carcinogenetic aflatoxins. However, there is a dearth of toxicity and potential cancer risk information regarding toxic alkaloids and aflatoxins via consuming AN products. The present study conducted a comprehensive assessment of the combined hazardous effects of AN alkaloids and aflatoxins towards human digestive system, by methods of HPLC analysis, cell study and in vitro digestive system study. The results revealed a synergetic effect of arecoline and aflatoxins was on human gingival normal fibroblast cell of HGF-1 and a proliferation effect on human tongue squamous carcinoma cell of CAL-27. Specifically, the residual arecoline was as high as 91.08 μg·ml-1 in oral phase and 72.41 μg·ml-1 in gastric phase, which could be an evidence of oral cancer. More importantly, 25.93 % of AN products were contaminated with aflatoxins and the maximum value was three times the MRLs. Under these circumstances, the cytotoxic and MOE values raised a considerable health concern in terms of malignancy risk for children that consume processed AN product, especially compared to scenarios that involve adults and/or fresh AN samples. This study would give rise to a better understanding of the hazards associated with AN alkaloids and aflatoxins towards digestive system, and thus to predict the potential carcinogenic risk of AN products.
科研通智能强力驱动
Strongly Powered by AbleSci AI