Operation Strategy for Avoiding Oiling‐Out During the Anti‐Solvent Crystallization Based on Ternary Phase Diagram

Abstract Oiling‐out occurs during the crystallization process and frequently cause deterioration of the characteristics of crystalline particles. In this study, operation strategies to avoid the oiling‐out in the anti‐solvent crystallization are investigated based on the ternary phase diagram. It is found that oiling‐out could be avoided by designing the trajectory of the operation point on the ternary phase diagram during the anti‐solvent crystallization. Additionally, the characteristics of crystalline particles is improved by avoiding the oiling‐out, which enables to obtain crystalline particles with high purity. The results show that the development of the operation method based on the ternary phase diagram is an effective strategy for avoiding the oiling‐out and producing the crystalline particles with favorable characteristics.