核糖核酸
RNA连接酶
DNA
寡核苷酸
核酸
生物化学
DNA连接酶
酶
化学
热稳定性
核酶
分子生物学
生物
立体化学
基因
作者
Shohei Kajimoto,Miwa Ohashi,Yusuke Hagiwara,Daisuke Takahashi,Yasuhiro Mihara,Tomoharu Motoyama,Sohei Ito,Shogo Nakano
摘要
RNA therapeutics is one of the next-generation medicines for treating various diseases. Our designed ancestral RNA ligase AncT4_2 exhibited excellent enzymatic properties, such as high thermal stability, productivity, specific activity, and broad substrate selectivity compared to native enzymes.
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