Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway

心脏毒性 槲皮素 顺铂 药理学 细胞凋亡 氧化应激 医学 炎症 抗氧化剂 化学 化疗 免疫学 生物化学 内科学
作者
Shih‐Hao Wang,Kun‐Ling Tsai,Wan‐Ching Chou,Hui-Ching Cheng,Yu‐Ting Huang,Hsiu‐Chung Ou,Yun‐Ching Chang
出处
期刊:The American Journal of Chinese Medicine [World Scientific]
卷期号:50 (05): 1281-1298 被引量:32
标识
DOI:10.1142/s0192415x22500537
摘要

Cisplatin is massively used to treat solid tumors. However, several severe adverse effects, such as cardiotoxicity, are obstacles to its clinical application. Cardiotoxicity may lead to congestive heart failure and even sudden cardiac death in patients receiving cisplatin. Therefore, finding a novel therapeutic strategy for the prevention of cisplatin-induced cardiotoxicity is urgent. Quercetin is a flavonol compound that can be found in dietary fruits and vegetables. The antioxidant function and anti-inflammatory capacity of quercetin have been reported. However, whether quercetin could protect against cisplatin-caused apoptosis and cellular damage in cardiomyocytes is still unclear. H9c2 cardiomyocytes were treated with cisplatin (40 μM) for 24 h to induce cellular damage with or without quercetin pretreatment. We found that quercetin activates Nrf2 and HO-1 expression, thereby mitigating cisplatin-caused cytotoxicity in H9c2 cells. Quercetin also increases SOD levels, maintains mitochondrial function, and reduces oxidative stress under cisplatin stimulation. Quercetin attenuates cisplatin-induced apoptosis and inflammation in H9c2 cardiomyocytes; however, these cytoprotective effects were diminished by silencing Nrf2 and HO-1. In conclusion, this study reports that quercetin has the potential to antagonize cisplatin-caused cardiotoxicity by reducing ROS-mediated mitochondrial damage and inflammation via the Nrf2/HO-1 and p38MAPK/NF-[Formula: see text]Bp65/IL-8 signaling pathway. This study provided the theoretical basis and experimental proof for the clinical application of quercetin as a new effective strategy to relieve chemotherapy-induced cardiotoxicity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
克苦的我发布了新的文献求助10
刚刚
胆XIAOXING发布了新的文献求助10
刚刚
刚刚
绒绒完成签到,获得积分10
刚刚
无私的鸣凤完成签到,获得积分10
1秒前
四维虫子完成签到,获得积分10
1秒前
1秒前
DRMelody完成签到,获得积分10
1秒前
2秒前
2秒前
12138完成签到,获得积分10
3秒前
3秒前
星辰大海应助liulala采纳,获得10
3秒前
傅傅完成签到,获得积分10
3秒前
21发布了新的文献求助10
4秒前
搜集达人应助Jessie采纳,获得10
4秒前
斯文败类应助子车凡采纳,获得10
4秒前
受伤南霜发布了新的文献求助10
5秒前
5秒前
5秒前
研白发布了新的文献求助10
5秒前
云桑完成签到 ,获得积分10
6秒前
瘦瘦小萱发布了新的文献求助10
6秒前
辅仁完成签到,获得积分10
7秒前
金秋完成签到,获得积分0
7秒前
丹霞应助ODD采纳,获得10
8秒前
bkagyin应助健壮问兰采纳,获得10
8秒前
panyuz发布了新的文献求助10
8秒前
英姑应助mmx采纳,获得10
8秒前
绒绒发布了新的文献求助10
8秒前
丘比特应助一堃采纳,获得10
9秒前
9秒前
小狗才喝冰红茶完成签到,获得积分10
10秒前
11秒前
科研通AI2S应助科研劝退采纳,获得10
12秒前
12秒前
郭囯完成签到,获得积分10
12秒前
小二郎应助瘦瘦小萱采纳,获得10
13秒前
13秒前
13秒前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3181376
求助须知:如何正确求助?哪些是违规求助? 2831591
关于积分的说明 7985655
捐赠科研通 2493611
什么是DOI,文献DOI怎么找? 1330220
科研通“疑难数据库(出版商)”最低求助积分说明 635954
版权声明 602955