亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway

心脏毒性 槲皮素 顺铂 药理学 细胞凋亡 氧化应激 医学 炎症 抗氧化剂 化学 化疗 免疫学 生物化学 内科学
作者
Shih‐Hao Wang,Kun‐Ling Tsai,Wan‐Ching Chou,Hui-Ching Cheng,Yu‐Ting Huang,Hsiu‐Chung Ou,Yun‐Ching Chang
出处
期刊:The American Journal of Chinese Medicine [World Scientific]
卷期号:50 (05): 1281-1298 被引量:32
标识
DOI:10.1142/s0192415x22500537
摘要

Cisplatin is massively used to treat solid tumors. However, several severe adverse effects, such as cardiotoxicity, are obstacles to its clinical application. Cardiotoxicity may lead to congestive heart failure and even sudden cardiac death in patients receiving cisplatin. Therefore, finding a novel therapeutic strategy for the prevention of cisplatin-induced cardiotoxicity is urgent. Quercetin is a flavonol compound that can be found in dietary fruits and vegetables. The antioxidant function and anti-inflammatory capacity of quercetin have been reported. However, whether quercetin could protect against cisplatin-caused apoptosis and cellular damage in cardiomyocytes is still unclear. H9c2 cardiomyocytes were treated with cisplatin (40 μM) for 24 h to induce cellular damage with or without quercetin pretreatment. We found that quercetin activates Nrf2 and HO-1 expression, thereby mitigating cisplatin-caused cytotoxicity in H9c2 cells. Quercetin also increases SOD levels, maintains mitochondrial function, and reduces oxidative stress under cisplatin stimulation. Quercetin attenuates cisplatin-induced apoptosis and inflammation in H9c2 cardiomyocytes; however, these cytoprotective effects were diminished by silencing Nrf2 and HO-1. In conclusion, this study reports that quercetin has the potential to antagonize cisplatin-caused cardiotoxicity by reducing ROS-mediated mitochondrial damage and inflammation via the Nrf2/HO-1 and p38MAPK/NF-[Formula: see text]Bp65/IL-8 signaling pathway. This study provided the theoretical basis and experimental proof for the clinical application of quercetin as a new effective strategy to relieve chemotherapy-induced cardiotoxicity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
5秒前
呆萌发布了新的文献求助10
8秒前
JamesPei应助呆萌采纳,获得10
22秒前
Yasong完成签到 ,获得积分10
34秒前
香芹又青完成签到,获得积分20
50秒前
不安的裘完成签到 ,获得积分10
1分钟前
orixero应助香芹又青采纳,获得30
1分钟前
rara完成签到,获得积分10
1分钟前
1分钟前
1分钟前
rara发布了新的文献求助10
1分钟前
1分钟前
FEI发布了新的文献求助10
2分钟前
酷波er应助FEI采纳,获得10
2分钟前
所所应助阿溪采纳,获得10
2分钟前
3分钟前
科目三应助科研通管家采纳,获得10
3分钟前
zz发布了新的文献求助10
3分钟前
4分钟前
4分钟前
呆萌发布了新的文献求助10
5分钟前
Lucas应助呆萌采纳,获得10
5分钟前
在水一方应助科研通管家采纳,获得10
5分钟前
Ava应助科研通管家采纳,获得10
5分钟前
5分钟前
大胆的凡儿完成签到 ,获得积分10
5分钟前
5分钟前
领导范儿应助JUSTs0so采纳,获得10
5分钟前
李健的小迷弟应助morena采纳,获得50
6分钟前
6分钟前
呆萌发布了新的文献求助10
6分钟前
共享精神应助风趣的忆南采纳,获得10
6分钟前
星辰大海应助maibaobao采纳,获得10
6分钟前
思源应助morena采纳,获得50
6分钟前
6分钟前
6分钟前
呆萌完成签到,获得积分20
6分钟前
6分钟前
7分钟前
asdfqaz完成签到,获得积分10
7分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Write Like a Chemist: A Guide and Resource (第二版) 600
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3200737
求助须知:如何正确求助?哪些是违规求助? 2850496
关于积分的说明 8072154
捐赠科研通 2514239
什么是DOI,文献DOI怎么找? 1346973
科研通“疑难数据库(出版商)”最低求助积分说明 640303
邀请新用户注册赠送积分活动 610411