Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway

心脏毒性 槲皮素 顺铂 药理学 细胞凋亡 氧化应激 医学 炎症 抗氧化剂 化学 化疗 免疫学 生物化学 内科学
作者
Shih‐Hao Wang,Kun‐Ling Tsai,Wan‐Ching Chou,Hui-Ching Cheng,Yu‐Ting Huang,Hsiu‐Chung Ou,Yun‐Ching Chang
出处
期刊:The American Journal of Chinese Medicine [World Scientific]
卷期号:50 (05): 1281-1298 被引量:32
标识
DOI:10.1142/s0192415x22500537
摘要

Cisplatin is massively used to treat solid tumors. However, several severe adverse effects, such as cardiotoxicity, are obstacles to its clinical application. Cardiotoxicity may lead to congestive heart failure and even sudden cardiac death in patients receiving cisplatin. Therefore, finding a novel therapeutic strategy for the prevention of cisplatin-induced cardiotoxicity is urgent. Quercetin is a flavonol compound that can be found in dietary fruits and vegetables. The antioxidant function and anti-inflammatory capacity of quercetin have been reported. However, whether quercetin could protect against cisplatin-caused apoptosis and cellular damage in cardiomyocytes is still unclear. H9c2 cardiomyocytes were treated with cisplatin (40 μM) for 24 h to induce cellular damage with or without quercetin pretreatment. We found that quercetin activates Nrf2 and HO-1 expression, thereby mitigating cisplatin-caused cytotoxicity in H9c2 cells. Quercetin also increases SOD levels, maintains mitochondrial function, and reduces oxidative stress under cisplatin stimulation. Quercetin attenuates cisplatin-induced apoptosis and inflammation in H9c2 cardiomyocytes; however, these cytoprotective effects were diminished by silencing Nrf2 and HO-1. In conclusion, this study reports that quercetin has the potential to antagonize cisplatin-caused cardiotoxicity by reducing ROS-mediated mitochondrial damage and inflammation via the Nrf2/HO-1 and p38MAPK/NF-[Formula: see text]Bp65/IL-8 signaling pathway. This study provided the theoretical basis and experimental proof for the clinical application of quercetin as a new effective strategy to relieve chemotherapy-induced cardiotoxicity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小二郎应助宋宋采纳,获得10
刚刚
一目发布了新的文献求助10
刚刚
123应助腼腆的斩采纳,获得10
1秒前
2秒前
111发布了新的文献求助10
2秒前
jilingfenghuang完成签到,获得积分10
2秒前
2秒前
4秒前
Harry应助weulo采纳,获得20
6秒前
调研昵称发布了新的文献求助10
6秒前
T拐拐发布了新的文献求助10
6秒前
华仔应助不知道叫啥采纳,获得10
7秒前
卡卡发布了新的文献求助10
7秒前
飞在夏夜的猫完成签到,获得积分10
7秒前
Leo发布了新的文献求助10
8秒前
包容可乐完成签到,获得积分10
10秒前
10秒前
学fei了吗完成签到,获得积分10
10秒前
调研昵称发布了新的文献求助10
10秒前
善学以致用应助一目采纳,获得10
12秒前
guoguo发布了新的文献求助10
12秒前
13秒前
雷寒云发布了新的文献求助30
13秒前
13秒前
kkdkg发布了新的文献求助30
14秒前
阳光的晓夏完成签到 ,获得积分10
15秒前
可爱的函函应助皮不可采纳,获得10
15秒前
asdwind完成签到,获得积分10
16秒前
线性谐振子完成签到,获得积分10
17秒前
18秒前
辞南完成签到,获得积分10
20秒前
SciGPT应助星星采纳,获得10
21秒前
22秒前
伊伊发布了新的文献求助10
23秒前
23秒前
啦啦啦哟完成签到,获得积分10
24秒前
24秒前
25秒前
27秒前
27秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3184620
求助须知:如何正确求助?哪些是违规求助? 2834922
关于积分的说明 8002218
捐赠科研通 2497295
什么是DOI,文献DOI怎么找? 1332783
科研通“疑难数据库(出版商)”最低求助积分说明 636685
邀请新用户注册赠送积分活动 604062