Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway

心脏毒性 槲皮素 顺铂 药理学 细胞凋亡 氧化应激 医学 炎症 抗氧化剂 化学 化疗 免疫学 生物化学 内科学
作者
Shih‐Hao Wang,Kun‐Ling Tsai,Wan‐Ching Chou,Hui-Ching Cheng,Yu‐Ting Huang,Hsiu‐Chung Ou,Yun‐Ching Chang
出处
期刊:The American Journal of Chinese Medicine [World Scientific]
卷期号:50 (05): 1281-1298 被引量:32
标识
DOI:10.1142/s0192415x22500537
摘要

Cisplatin is massively used to treat solid tumors. However, several severe adverse effects, such as cardiotoxicity, are obstacles to its clinical application. Cardiotoxicity may lead to congestive heart failure and even sudden cardiac death in patients receiving cisplatin. Therefore, finding a novel therapeutic strategy for the prevention of cisplatin-induced cardiotoxicity is urgent. Quercetin is a flavonol compound that can be found in dietary fruits and vegetables. The antioxidant function and anti-inflammatory capacity of quercetin have been reported. However, whether quercetin could protect against cisplatin-caused apoptosis and cellular damage in cardiomyocytes is still unclear. H9c2 cardiomyocytes were treated with cisplatin (40 μM) for 24 h to induce cellular damage with or without quercetin pretreatment. We found that quercetin activates Nrf2 and HO-1 expression, thereby mitigating cisplatin-caused cytotoxicity in H9c2 cells. Quercetin also increases SOD levels, maintains mitochondrial function, and reduces oxidative stress under cisplatin stimulation. Quercetin attenuates cisplatin-induced apoptosis and inflammation in H9c2 cardiomyocytes; however, these cytoprotective effects were diminished by silencing Nrf2 and HO-1. In conclusion, this study reports that quercetin has the potential to antagonize cisplatin-caused cardiotoxicity by reducing ROS-mediated mitochondrial damage and inflammation via the Nrf2/HO-1 and p38MAPK/NF-[Formula: see text]Bp65/IL-8 signaling pathway. This study provided the theoretical basis and experimental proof for the clinical application of quercetin as a new effective strategy to relieve chemotherapy-induced cardiotoxicity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
yudandan@CJLU发布了新的文献求助10
1秒前
浩二应助xiw采纳,获得10
1秒前
zzn完成签到,获得积分10
1秒前
2秒前
bbmm发布了新的文献求助30
2秒前
劳模发布了新的文献求助10
3秒前
zzn发布了新的文献求助10
5秒前
5秒前
5秒前
5秒前
小马甲应助YUMMY采纳,获得10
7秒前
全圆佑的猫猫完成签到,获得积分10
7秒前
www完成签到,获得积分10
7秒前
lalala应助wwnd采纳,获得10
8秒前
cloudmeadow完成签到,获得积分20
8秒前
paxton完成签到,获得积分10
8秒前
cruise发布了新的文献求助10
9秒前
ahaaa发布了新的文献求助10
10秒前
10秒前
科研通AI2S应助平常亦凝采纳,获得10
10秒前
科研通AI2S应助ydq采纳,获得10
11秒前
小蘑菇应助AFsumo采纳,获得10
11秒前
兴奋土豆发布了新的文献求助10
12秒前
13秒前
Devin Irving完成签到,获得积分10
15秒前
15秒前
脑洞疼应助陈ber裤腰带采纳,获得10
15秒前
研友_VZG7GZ应助尊敬寒松采纳,获得10
15秒前
yudandan@CJLU发布了新的文献求助10
15秒前
啊哈关注了科研通微信公众号
15秒前
17秒前
17秒前
毛毛虫发布了新的文献求助10
17秒前
Devin Irving发布了新的文献求助10
17秒前
科研通AI2S应助JUDY采纳,获得10
19秒前
迷茫兽医完成签到,获得积分10
19秒前
19秒前
19秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
India's foreign trade policy and its performance in the world economy 450
Structural Inorganic Chemistry 400
Dictionary of socialism 350
Mixed-anion Compounds 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196121
求助须知:如何正确求助?哪些是违规求助? 2844892
关于积分的说明 8052117
捐赠科研通 2509514
什么是DOI,文献DOI怎么找? 1341768
科研通“疑难数据库(出版商)”最低求助积分说明 639262
邀请新用户注册赠送积分活动 608445