摘要
Biochemistry and physiology of brain ammonia.A J Cooper, and F PlumA J Cooper, and F PlumPublished Online:01 Apr 1987https://doi.org/10.1152/physrev.1987.67.2.440MoreSectionsPDF (13 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByAir-breathing and excretory nitrogen metabolism in fishesActa Histochemica, Vol. 120, No. 7New in vitro model derived from brain-specific Mut-/- mice confirms cerebral ammonium accumulation in methylmalonic aciduriaMolecular Genetics and Metabolism, Vol. 124, No. 4Influence of implementing a protocol for an intravenously administered ammonia scavenger on the management of acute hyperammonemia in a pediatric intensive care unit5 June 2018 | Journal of Inherited Metabolic Disease, Vol. 12Efficacy and safety of rifaximin in Japanese patients with hepatic encephalopathy: A phase II/III, multicenter, randomized, evaluator-blinded, active-controlled trial and a phase III, multicenter, open trial19 January 2018 | Hepatology Research, Vol. 48, No. 6Blood Ammonia as a Possible Etiological Agent for Alzheimer’s Disease4 May 2018 | Nutrients, Vol. 10, No. 5Hyperammonemic encephalopathy in a patient receiving fluorouracil/oxaliplatin chemotherapy13 February 2018 | Clinical Case Reports, Vol. 6, No. 4The effects of high environmental ammonia on the structure of rainbow trout hierarchies and the physiology of the individuals thereinAquatic Toxicology, Vol. 195Inherited hyperammonemias: a Contemporary view on pathogenesis and diagnosis27 December 2017 | Expert Opinion on Orphan Drugs, Vol. 6, No. 2Physiology of AstrogliaAlexei Verkhratsky and Maiken Nedergaard12 December 2017 | Physiological Reviews, Vol. 98, No. 1Effects of Exposure to Ammonia on Plasma, Brain and Muscle Concentrations of Amino Acids and Adenyl Nucleotides in the Siberian Sturgeon, Acipenser baerii11 July 2017Hepatic Encephalopathy: Pathophysiology—Brain24 May 2018Which of the branched-chain amino acids increases cerebral blood flow in hepatic encephalopathy? 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I. Ammonia and glutamine contents and glutamate dehydrogenase activityMechanisms of Ageing and Development, Vol. 68, No. 1-3Ammonia potentiates GABAA response in dissociated rat cortical neuronsNeuroscience Letters, Vol. 151, No. 1Effect of sodium benzoate on cerebral and hepatic energy metabolites in spf mice with congenital hyperammonemiaBiochemical Pharmacology, Vol. 45, No. 1The influence of manganese supplementation on seizure onset and severity, and brain monoamines in the genetically epilepsy prone ratEpilepsy Research, Vol. 14, No. 1Chronic hyperammonemia prevents changes in brain energy and ammonia metabolites induced by acute ammonium intoxicationBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1180, No. 3NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain29 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 12, No. 3Hyperammonemia induces transient GFAP immunoreactivity changes in goldfish spinal cord (Carassius auratus L.)Neuroscience Research, Vol. 13, No. 3Hyperammonemic alterations in the metabolism of glutamate and aspartate in rat cerebellar astrocytesNeuroscience Letters, Vol. 138, No. 1Suppression of neurotoxicity of ammonia by l-carnitineBrain Research, Vol. 567, No. 2Decreased potassium-stimulated release of [3H]d-aspartate from hippocampal slices distinguishes encephalopathy related to acute liver failure from that induced by simple hyperammonemiaBrain Research, Vol. 567, No. 1Portacaval anastomosis disrupts circadian locomotor activity and pineal melatonin rhythms in ratsBrain Research, Vol. 560, No. 1-2Ammonia-induced alterations in glutamate and muscimol binding to cerebellar synaptic membranesNeuroscience Letters, Vol. 130, No. 2l-carnitine protection in ammonia intoxicationBiochemical Pharmacology, Vol. 41, No. 12A 15N-NMR study of isolated brain in portacaval-shunted rats after acute hyperammonemiaBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1096, No. 4Effects of ammonium on energy metabolism and intracellular pH in guinea pig cerebral cortex studied by 31P and 1H nuclear magnetic resonance spectroscopyNeurochemistry International, Vol. 19, No. 4Different responses of rat cerebral mitochondrial 2-oxoglutarate dehydrogenase activity to ammonia and hepatic encephalopathy in synaptic and nonsynaptic mitochondriaNeurochemistry International, Vol. 19, No. 4The Flux from Glucose to Glutamate in the Rat Brain in vivo as Determined by 1 -Observed, 13 C-Edited NMR Spectroscopy28 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 10, No. 2Effect of methionine sulfoximine on pyruvate dehydrogenase, citric acid cycle enzymes and aminotransferases in the subcellular fractions isolated from rat cerebral cortexNeuroscience Letters, Vol. 108, No. 3Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's diseaseNeuroscience, Vol. 38, No. 3Neurochemical and electrophysiological studies on the inhibitory effect of ammonium ions on synaptic transmission in slices of rat hippocampus: Evidence for a postsynaptic actionNeuroscience, Vol. 37, No. 2Functional changes of brain mitochondria during experimental hepatic encephalopathyBiochemical Pharmacology, Vol. 38, No. 21The changes in activities of some ammonia metabolizing enzymes in liver and brain of rats intoxicated by chronic administration of acetaldehydeBiochemical Pharmacology, Vol. 38, No. 17Neurologic Manifestations of Hepatic DiseaseNeurologic Clinics, Vol. 7, No. 3Ammonia causes a drop in intracellular pH in metabolizing cortical brain slices. A [31P]- and [1H]nuclear magnetic resonance studyNeuroscience, Vol. 33, No. 1Changes in activities of some ammonia-metabolizing enzymes in the rat liver and the brain affer chronic ethanol administrationBiochemical Medicine and Metabolic Biology, Vol. 40, No. 3Isolation of a cDNA for rat brain glutaminaseMolecular Brain Research, Vol. 3, No. 3 More from this issue > Volume 67Issue 2April 1987Pages 440-519 Copyright & PermissionsCopyright © 1987 by American Physiological Societyhttps://doi.org/10.1152/physrev.1987.67.2.440PubMed2882529History Published online 1 April 1987 Published in print 1 April 1987 Metrics