医学
无花果素
补体系统
类风湿性关节炎
丙泊酚
混淆
胰岛素抵抗
免疫学
代谢综合征
内科学
关节炎
凝集素途径
甘露聚糖结合凝集素
凝集素
胰岛素
替代补体途径
免疫系统
肥胖
作者
Dara Rodríguez-González,María García-González,Fuensanta Gómez-Bernal,Juan Carlos Quevedo-Abeledo,Agustín F. González-Rivero,Elena González-López,J. Gonzalo Ocejo‐Vinyals,Miguel Á. González‐Gay,Iván Ferraz‐Amaro
标识
DOI:10.3899/jrheum.2024-0437
摘要
Objective The complement system has been associated with the etiopathogenesis of rheumatoid arthritis (RA). Insulin resistance (IR) and metabolic syndrome (MetS) are prevalent among patients with RA. The aim of this study was to explore the relationship between a comprehensive evaluation of the complement system and IR, as well as MetS, in patients with RA. Methods A total of 339 nondiabetic patients with RA were recruited. Functional assays of the 3 complement pathways were assessed. Additionally, serum levels of the following individual components of the complement system were measured: C1q (classical); lectin (lectin); C2, C4, and C4b (classical lectin); factor D and properdin (alternative); C3 and C3a (common); C5, C5a, and C9 (terminal); as well as the factor I and C1 inhibitor regulators. IR and β cell function indices were calculated using the homeostatic model assessment. Criteria for MetS were applied. Multivariable linear regression analysis was performed to investigate the association between the complement system and IR in patients with RA. Results Many elements of the upstream and common complement pathways, but not the functional tests of the 3 routes, correlated positively with higher levels of IR and β cell function. However, after multivariable adjustment for factors associated with IR, these relationships were lost. Conversely, the presence of MetS in patients with RA maintained a relationship with higher levels of C1q, C4, C3, properdin, and factor I after adjusting for confounders. Conclusion There is a positive correlation between the complement system and MetS among nondiabetic patients with RA. This association is independent of traditional IR factors.
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