T细胞受体
胸腺细胞
CD3型
生物
信号转导
受体
细胞生物学
细胞内
T细胞
细胞表面受体
免疫学
免疫系统
遗传学
CD8型
标识
DOI:10.1111/j.1600-065x.2009.00835.x
摘要
Summary: Assembly, expression, and signal transduction by the pre‐T‐cell receptor (pre‐TCR) and TCR complexes are critical for normal thymocyte development. How environmental cues sensed by these two receptor complexes are translated into biological responses that result in the generation of functionally mature T cells is increasingly better understood. Invariant CD3γ, δ, ε, and ζ polypeptides are central to the function of these two receptor complexes. CD3 chains ensure correct intracellular assembly, surface expression, and signal transduction via the receptors in ligand‐independent and ‐dependent manners. In the present review, the roles of the CD3 chains, particularly CD3γ, δ, and ε, in thymocyte differentiation in mice and humans are reviewed.
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