Hyperuricemia in Diabetic Ketoacidosis

THERE is considerable clinical1 2 3 4 5 6 7 and biochemical8 , 9 evidence suggesting but not firmly establishing a relation of uric acid with carbohydrate and lipid metabolism. Uric acid resembles alloxan in its chemical configuration, and there have been preliminary observations provoking the concept of "uric acid diabetes."8 , 9 Although the diabetogenic effects of uric acid have not been proved to exist in man there is at least some statistical evidence of a high incidence of diabetes with hyperuricemia or gout or both.3 , 7 Other observations include the influence of insulin on precipitating acute gout,10 the coincidence of hypercholesterolemia,3 hyperuricemia and hyperglycemia11 and the effects of starvation, . . .