结直肠癌
激素
肠易激综合征
恶性肿瘤
内科学
医学
疾病
憩室炎
生理学
内分泌学
病理生理学
生物信息学
生物
癌症
作者
Afnan Banibakhsh,Daljit Sidhu,Seema A. Khan,Hope Haime,Paul A. Foster
标识
DOI:10.1016/j.jsbmb.2023.106371
摘要
The colon is the largest hormonally active tissue in the human body. It has been known for over a hundred years that various hormones and bioactive peptides play important roles in colon function. More recently there is a growing interest in the role the sex steroids, oestrogens and androgens, may play in both normal colon physiology and colon pathophysiology. In this review, we examine the potential role oestrogens and androgens play in the colon. The metabolism and subsequent action of sex steroids in colonic tissue is discussed and how these hormones impact colon motility is investigated. Furthermore, we also determine how oestrogens and androgens influence colorectal cancer incidence and development and highlight potential new therapeutic targets for this malignancy. This review also examines how sex steroids potentially impact the severity and progression of other colon disease, such as diverticulitis, irritable bowel syndrome, and polyp formation.
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