Therapeutic approaches targeting oncogenic proteins in myeloid leukemia: challenges and perspectives

Leukemia is typically categorized into myeloid leukemia and lymphoblastic leukemia based on the origins of leukemic cell. Myeloid leukemia is a group of clonal malignancies characterized by the presence of increased immature myeloid cells in both bone marrow and peripheral blood. Of note, the aberrant expression of specific proteins or the generation of fusion proteins due to chromosomal abnormalities are well established drivers in various forms of myeloid leukemia. Therefore, these oncoproteins represent promising targets for drug development.