Urinary Syndecan-1 and acute kidney injury after pediatric cardiac surgery

医学 急性肾损伤 泌尿系统 生物标志物 肌酐 透析 辛迪康1 前瞻性队列研究 泌尿科 四分位数 内科学 外科 置信区间 生物化学 化学 遗传学 生物 细胞
作者
Natalia Monte Benevides Ferrer,Candice Torres de Melo Bezerra Cavalcante,Klébia Magalhães Castelo Branco,Valdester Cavalcante Pinto Júnior,Gdayllon Cavalcante Meneses,Fernanda Macedo de Oliveira Neves,Nayana Maria Gomes de Souza,Kiarelle LourençoPenaforte,Alice Maria Costa Martins,Alexandre Braga Libório
出处
期刊:Clinica Chimica Acta [Elsevier BV]
卷期号:485: 205-209 被引量:13
标识
DOI:10.1016/j.cca.2018.06.033
摘要

Acute kidney injury (AKI) is a common occurrence after pediatric cardiac surgery. Plasma syndecan-1 is a biomarker of endothelial glycocalyx damage and it is associated with AKI. Syndecan-1 is also expressed in renal tubular cells but there is no study evaluating urinary syndecan-1 in predicting AKI.Prospective cohort study with 86 patients ≤18 years submitted to cardiac surgery at one reference institution. Postoperative urinary syndecan-1 was collected within the first 2 h after cardiac surgery. Severe AKI - defined according to KDIGO as stage 2 or 3 - doubling of serum creatinine from the preoperative value or need for dialysis during hospitalization was the main outcome. Analyses were adjusted for clinical cofounders.Postoperative urinary syndecan-1 levels were higher in patients with severe AKI and even after adjustment for several clinical variables; the fourth quartile was significantly associated with severe AKI. The AUC-ROC for postoperative urinary syndecan-1 showed good discriminatory capacity (AUC-ROC = 0.793). The addition of urinary syndecan-1 improved the discrimination capacity of a clinical model (0.78 to 0.84). It also improved risk prediction, as measured by net reclassification improvement (NRI).Urinary syndecan-1 predicts severe AKI after pediatric cardiac surgery. Moreover, it appears to add capacity to predict severe AKI into a clinical model.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
刚刚
1秒前
2秒前
2秒前
善学以致用应助薛华倩采纳,获得10
4秒前
huqingtao完成签到,获得积分10
4秒前
了了完成签到,获得积分10
4秒前
5秒前
5秒前
666完成签到,获得积分10
6秒前
9秒前
10秒前
星辰大海应助樱桃窝窝头采纳,获得10
11秒前
258369完成签到,获得积分10
12秒前
13秒前
14秒前
Sunwenrui发布了新的文献求助10
15秒前
薛华倩发布了新的文献求助10
19秒前
白白SAMA123发布了新的文献求助10
19秒前
19秒前
昏睡的飞机完成签到,获得积分10
19秒前
20秒前
21秒前
23秒前
miaojuly发布了新的文献求助10
23秒前
共享精神应助追寻筮采纳,获得10
23秒前
24秒前
莫歌完成签到 ,获得积分10
24秒前
2889580752发布了新的文献求助10
25秒前
量子星尘发布了新的文献求助10
25秒前
杨冠文发布了新的文献求助10
25秒前
HOME发布了新的文献求助10
27秒前
liz_应助努力工作的人采纳,获得10
28秒前
Lycerdoctor发布了新的文献求助10
28秒前
东瓜魔法师完成签到,获得积分10
28秒前
杨冠文完成签到,获得积分10
30秒前
30秒前
Owen应助肖肖采纳,获得10
31秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035