免疫系统
肿瘤微环境
免疫疗法
癌症免疫疗法
受体
生物
Toll样受体
先天免疫系统
免疫学
模式识别受体
潮湿
癌症研究
生物化学
物理
气象学
作者
Hideyuki Yanai,Sho Hangai,Tadatsugu Taniguchi
标识
DOI:10.1093/intimm/dxab050
摘要
As clinically demonstrated by the success of immunotherapies to improve survival outcomes, tumors are known to gain a survival advantage by circumventing immune surveillance. A defining feature of this is the creation and maintenance of a tumor immune microenvironment (TIME) that directly and indirectly alters the host's immunologic signaling pathways through a variety of mechanisms. Tumor-intrinsic mechanisms that instruct the formation and maintenance of the TIME have been an area of intensive study, such as the identification and characterization of soluble factors actively and passively released by tumor cells that modulate immune cell function. In particular, damage-associated molecular pattern (DAMP) molecules typically released by necrotic tumor cells are recognized by innate immune receptors such as Toll-like receptors (TLRs) and stimulate immune cells within TIME. Given their broad and potent effects on the immune system, a better understanding for how DAMP and TLR interactions sculpt the TIME to favor tumor growth would identify new strategies and approaches for cancer immunotherapy.
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