化学
组合化学
激酶
生物活性
计算生物学
药理学
生物化学
生物
体外
作者
Vincent Ferrières,Karim Jarmoni,K. Misbahi
标识
DOI:10.2174/0929867330666230426111650
摘要
Abstract: Imidazo[4,5-b]pyridines are amongst the oldest known heteroaromatic derivatives. Their structural similarity with purine basis has however aroused the curiosity of biologists and resulted in the developments of innovative bioactive compounds. This review thus firstly describes the main synthetic ways currently used to produce imidazo[ 4,5-b]pyridine derivatives, and secondly gives examples of their potential, especially focusing on protein inhibition abilities, thus opening the way to applications as anti-cancer or antimicrobial agents.
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