产量(工程)
HEK 293细胞
悬挂(拓扑)
载体(分子生物学)
生物
化学
细胞培养
遗传学
物理
重组DNA
数学
基因
同伦
纯数学
热力学
作者
Kimberly L. Pietersz,Paul J H Nijhuis,Matthijs H M Klunder,Joëlle van den Herik,Barbara Hobo,Fred de Winter,Joost Verhaagen
摘要
Adeno-associated viral vectors (AAVs) are a remarkable tool for investigating the central nervous system (CNS). Innovative capsids, such as AAV.PHP.eB, demonstrate extensive transduction of the CNS by intravenous injection in mice. To achieve comparable transduction, a 100-fold higher titer (minimally 1 x 10
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