Adaptive Changes in Detoxification Metabolism and Transmembrane Transport of Bombyx mori Malpighian Tubules to Artificial Diet

马尔皮基亚小管系统 家蚕 生物 生物化学 戒毒(替代医学) 代谢途径 新陈代谢 细胞色素P450 异型生物质的 代谢组 基因 植物 代谢物 医学 病理 中肠 幼虫 替代医学
作者
Lijing Liu,Dongchao Zhao,Genhong Wang,Qingxiu He,Yuwei Song,Yulu Jiang,Qingyou Xia,Ping Zhao
出处
期刊:International Journal of Molecular Sciences [MDPI AG]
卷期号:24 (12): 9949-9949 被引量:6
标识
DOI:10.3390/ijms24129949
摘要

The high adaptability of insects to food sources has contributed to their ranking among the most abundant and diverse species on Earth. However, the molecular mechanisms underlying the rapid adaptation of insects to different foods remain unclear. We explored the changes in gene expression and metabolic composition of the Malpighian tubules as an important metabolic excretion and detoxification organ in silkworms (Bombyx mori) fed mulberry leaf and artificial diets. A total of 2436 differentially expressed genes (DEGs) and 245 differential metabolites were identified between groups, with the majority of DEGs associated with metabolic detoxification, transmembrane transport, and mitochondrial function. Detoxification enzymes, such as cytochrome P450 (CYP), glutathione-S-transferase (GST), and UDP-glycosyltransferase, and ABC and SLC transporters of endogenous and exogenous solutes were more abundant in the artificial diet group. Enzyme activity assays confirmed increased CYP and GST activity in the Malpighian tubules of the artificial diet-fed group. Metabolome analysis showed increased contents of secondary metabolites, terpenoids, flavonoids, alkaloids, organic acids, lipids, and food additives in the artificial diet group. Our findings highlight the important role of the Malpighian tubules in adaptation to different foods and provide guidance for further optimization of artificial diets to improve silkworm breeding.

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