Effect of vitamin C on parathyroid hormone in hemodialysis patients with mild to moderate secondary hyperparathyroidism.

医学 继发性甲状旁腺功能亢进 甲状旁腺激素 血液透析 内科学 内分泌学 甲状旁腺功能亢进 维生素D与神经学 泌尿科 胃肠病学
作者
Houshang Sanadgol,Mahtab Bayani,Mahdi Mohammadi,Baktash Bayani,Mohammad Ali Mashhadi
出处
期刊:PubMed 卷期号:5 (6): 410-5 被引量:11
链接
标识
摘要

In end-stage renal disease, there is a high incidence of secondary hyperparathyroidism. It is proposed that increasing vitamin C levels by dietary supplementation results in a decrease of parathyroid hormone (PTH) in vitamin C-deficient hemodialysis patients with secondary hyperparathyroidism. The aim of this study was the evaluation of vitamin C administration for reduction of serum PTH level in hemodialysis patients.Twenty-one hemodialysis patients with serum PTH levels less than 550 pg/mL (but more than 200 pg/mL) were administered intravenous vitamin C, 200 mg, 3 times per week for 3 months. Blood samples for measurement of PTH were obtained at the beginning of the hemodialysis session every month for three months.The mean level of serum biointact PTH was 333.3 ± 141.3 pg/mL (reference range, 7 pg/mL to 82 pg/mL) at baseline, and it decreased to 256.5 ± 137.2 pg/mL at 1 month (P = .03). The mean PTH level was also lower than the baseline value at 2 months (260.1 ± 123.2 pg/mL, P = .03), while it increased to 328.9 ± 176.0 pg/mL at 3 months, which was still slightly lower than the baseline level (P = .13). In 15 patients (71.4%), serum levels of PTH were lower than the baseline at months 1 to 2, while in the remaining 6 (28.6%), it was higher than the baseline value. At 3 months, 5 of the 15 patients with lower PTH levels up to the 3rd month experienced an increase in these levels again.Administration of intravenous vitamin C in hemodialysis patients noticeably decreased level of PTH, but its effect gradually diminished.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zzx396完成签到,获得积分0
刚刚
666完成签到,获得积分10
刚刚
1秒前
拉长的晓蕾发布了新的文献求助100
1秒前
1秒前
ZONG完成签到,获得积分10
1秒前
Funny完成签到,获得积分10
2秒前
健康的雁凡完成签到,获得积分10
2秒前
林小昀完成签到 ,获得积分10
2秒前
科奇应助科研通管家采纳,获得10
2秒前
领导范儿应助科研通管家采纳,获得10
2秒前
2秒前
3秒前
墨痕mohen完成签到,获得积分10
3秒前
Muhi完成签到,获得积分10
3秒前
达到完成签到,获得积分10
3秒前
薄荷小新完成签到 ,获得积分10
4秒前
caozhi完成签到,获得积分10
4秒前
何为会完成签到,获得积分10
4秒前
顾矜应助七七采纳,获得10
5秒前
小鱼儿完成签到,获得积分10
5秒前
5秒前
yyyy完成签到,获得积分10
6秒前
马东完成签到,获得积分10
6秒前
成森完成签到,获得积分10
6秒前
爱吃大米发布了新的文献求助10
7秒前
7秒前
秋秋糖xte发布了新的文献求助10
8秒前
zyshao完成签到,获得积分10
8秒前
Lynn完成签到,获得积分10
8秒前
liuchao完成签到,获得积分10
8秒前
大模型应助焓晓芈采纳,获得10
9秒前
xyzdmmm完成签到,获得积分10
9秒前
Haibara5发布了新的文献求助10
10秒前
10秒前
凤迎雪飘完成签到,获得积分10
11秒前
叶子完成签到,获得积分10
11秒前
平淡的初翠完成签到 ,获得积分10
11秒前
甜甜穆完成签到,获得积分10
11秒前
豪的花花完成签到,获得积分10
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968593
求助须知:如何正确求助?哪些是违规求助? 3513416
关于积分的说明 11167791
捐赠科研通 3248853
什么是DOI,文献DOI怎么找? 1794507
邀请新用户注册赠送积分活动 875170
科研通“疑难数据库(出版商)”最低求助积分说明 804671