顶泌
细胞生物学
肌上皮细胞
胞质分裂
分泌物
生物
细胞质
肌球蛋白
解剖
免疫组织化学
细胞
细胞分裂
免疫学
内分泌学
生物化学
作者
Mechthild Stoeckelhuber,Christoph Schubert,Marco Kesting,Denys J. Loeffelbein,Markus Nieberler,Claudia Koehler,Ulrich Welsch
出处
期刊:Histology and Histopathology
日期:2011-02-01
卷期号:26 (2): 177-84
被引量:10
摘要
The apocrine secretory mechanism is a mode of secretion by which the apical part of the cell cytoplasm is pinched off, which leads to the formation of an aposome. The distinct mechanism of formation and decapitation of the aposome is not well investigated. Only few proteins are known that are involved in this secretory mechanism. We studied the human axillary apocrine gland and looked at proteins associated with cytokinesis, a process that is comparable to the pinching-off mechanism of apocrine glandular cells. By immunohistochemistry, we detected actin, myosin II, cytokeratin 7 and 19, α- and β-tubulin, anillin, cofilin, syntaxin 2, vamp8/endobrevin and septin 2. In highly active glandular cells, these proteins are located at the base of the apical protrusion when the aposome is in the process of being released or are concentrated in the cap of the apical protrusion. These findings demonstrate new insights on apocrine secretory mechanisms and point to similarities to the terminal step of cytokinesis, which is regulated by a SNARE-mediated membrane fusion event.
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