过氧亚硝酸盐
化学
体内
生物物理学
内生
荧光
体外
纳米技术
生物化学
生物
超氧化物
酶
量子力学
物理
生物技术
材料科学
作者
Jiaqi Xu,Meng-Jiao Gao,Jin-Shuang Guo,Yihua Wang,Ran Wei,Yali Meng,Yan‐Fei Kang
标识
DOI:10.1016/j.bioorg.2022.106055
摘要
In this study, we constructed and displayed a ratiometric fluorescent probe JQ-2 for detecting ONOO-. The probe JQ-2 showed a ratiometric signal for visualizing ONOO- with a rapid response and high selectivity over a panel of biological analytes. Moreover, the JQ-2 has near-infrared emission (657 nm), which provides an excellent basis for the practical application in biological systems. The probe JQ-2 possessed low cytotoxicity and excellent cell membrane permeability, which can specifically visualize the exogenous and endogenous ONOO- in vitro and vivo by emission in two channels. Meanwhile, JQ-2 can be used for diagnosing drug-induced liver injury by visualizing and monitoring the fluctuations of endogenous ONOO-. Therefore, JQ-2 provided a potential tool for precisely detecting the fluctuation of ONOO- in biological systems to understand physiological and pathological process.
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