纳米载体
药理学
医学
药代动力学
神经保护
固体脂质纳米粒
疾病
槲皮素
药品
药物输送
药效学
生物利用度
氧化应激
抗氧化剂
化学
病理
内科学
生物化学
有机化学
作者
Komaldeep Kaur,Yogesh A. Kulkarni,Sarika Wairkar
出处
期刊:Brain Research
[Elsevier]
日期:2024-03-31
卷期号:1834: 148905-148905
被引量:1
标识
DOI:10.1016/j.brainres.2024.148905
摘要
Alzheimer's disease (AD) is a primary cause of dementia that affects millions of people worldwide and its prevalence is likely to increase largely in the coming decades. Multiple complex pathways, such as oxidative stress, tau and amyloid-beta (Aβ) pathology, and cholinergic dysfunction, are involved in the pathogenesis of Alzheimer's disease. The conventional treatments provide only symptomatic relief and not a complete cure for the disease. On the other hand, recent studies have looked into the possibility of flavonoids as an effective therapeutic strategy for treating AD. Quercetin, a well-known flavonol, has been extensively studied for AD treatment. Therefore, this review mainly focuses on the pharmacokinetics properties of quercetin and its modes of action, such as antioxidant, anti-inflammatory, anti-amyloidogenic, and neuroprotective properties, which are beneficial in treating AD. It also highlights the nano delivery systems of quercetin, including liposomes, nanostructures lipid carriers, solid lipid nanoparticles, nanoemulsions, microemulsions, self-emulsifying drug delivery systems, and nanoparticles reported for AD treatment. The remarkable potential of quercetin nanocarriers has been reflected in enhancing its bioavailability and therapeutic efficacy. Therefore, clinical studies must be conducted to explore it as a therapeutic strategy for Alzheimer's disease.
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