已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Is Left Ventricular Systolic Dysfunction Associated With Increased Mortality Among Patients With Sepsis and Septic Shock?

医学 感染性休克 内科学 败血症 心脏病学 休克(循环)
作者
Siddharth Dugar,Ryota Sato,Sanchit Chawla,Jee Young You,Xiaofeng Wang,Richard A. Grimm,Patrick Collier,Michael J. Lanspa,Abhijit Duggal
出处
期刊:Chest [Elsevier BV]
卷期号:163 (6): 1437-1447 被引量:31
标识
DOI:10.1016/j.chest.2023.01.010
摘要

Background The impact of left ventricular systolic function on outcomes in patients with sepsis and septic shock remains uncertain. The association, if any, may be nonlinear. Research Question Is left ventricular systolic dysfunction associated with increased mortality among patients with sepsis and septic shock? Study Design and Methods Retrospective cohort study comprising all adult patients admitted to the medical intensive care unit (MICU) from January 1, 2011, to December 31, 2020, with sepsis and septic shock as defined by sepsis 3 guidelines. All adult patients with sepsis or septic shock who underwent transthoracic echocardiogram (TTE) within 3 days from admission to MICU were included. We divided patients into five groups based on LVEF. In addition to univariate analysis, we also performed multivariable logistic regression analysis adjusting for patients’ baseline characteristics and the severity of illness. The primary outcome was the association between each classification of LVEF and in-hospital mortality. Results A total of 3,151 patients were included in this study (LVEF <25%, 133 patients; 25%≤ LVEF <40%, 305 patients; 40%≤ LVEF <55%, 568 patients; 55%≤ LVEF <70%, 1,792 patients; and LVEF ≥70%, 353 patients). In-hospital mortalities in each LVEF category were 51.1%, 34.8%, 26.6%, 26.2%, and 41.9%, respectively. In the multivariable logistic regression analysis, LVEF <25% (OR, 2.75, 95% CI, 1.82-4.17, p< 0.001) and LVEF ≥70% (OR, 1.70; 95%CI, 1.09-1.88; p=0.010) were independently associated with significantly higher in-hospital mortality, compared to the reference LVEF category (55-70%). Interpretation The association of LVEF to in-hospital mortality in sepsis and septic shock was U-shaped. Both severe LV systolic dysfunction (LVEF <25%) and hyper-dynamic LVEF (LVEF ≥70%) were independently associated with significantly higher in-hospital mortality.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
4秒前
阿司匹林完成签到,获得积分10
4秒前
5秒前
General发布了新的文献求助10
6秒前
djam完成签到,获得积分20
6秒前
小光光鸡鸡爆完成签到 ,获得积分10
6秒前
Hello应助科研通管家采纳,获得10
8秒前
赘婿应助科研通管家采纳,获得10
8秒前
汉堡包应助科研通管家采纳,获得10
8秒前
科研通AI2S应助科研通管家采纳,获得10
8秒前
华仔应助科研通管家采纳,获得10
8秒前
8秒前
FashionBoy应助科研通管家采纳,获得10
8秒前
8秒前
8秒前
科研通AI5应助科研通管家采纳,获得10
8秒前
9秒前
9秒前
ED应助U9A采纳,获得10
10秒前
11秒前
丘比特应助Ahiterin采纳,获得80
12秒前
12秒前
Mars_1108发布了新的文献求助10
13秒前
13秒前
余子健完成签到 ,获得积分10
14秒前
rita4616发布了新的文献求助10
15秒前
djam发布了新的文献求助10
15秒前
16秒前
余子健关注了科研通微信公众号
16秒前
17秒前
有魅力强炫完成签到 ,获得积分10
19秒前
20秒前
choo发布了新的文献求助10
20秒前
芯之痕发布了新的文献求助10
21秒前
Candy2024完成签到 ,获得积分10
21秒前
俏皮的白柏完成签到,获得积分10
22秒前
liu完成签到 ,获得积分10
25秒前
wendy完成签到,获得积分10
25秒前
英姑应助科研蜗牛采纳,获得10
25秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976512
求助须知:如何正确求助?哪些是违规求助? 3520548
关于积分的说明 11203949
捐赠科研通 3257210
什么是DOI,文献DOI怎么找? 1798648
邀请新用户注册赠送积分活动 877835
科研通“疑难数据库(出版商)”最低求助积分说明 806555