芘
肺癌
环境化学
致癌物
人口
癌症
环境卫生
环境科学
风险评估
煤
毒理
化学
医学
生物
肿瘤科
有机化学
内科学
计算机安全
计算机科学
作者
Lord Famiyeh,Honghui Xu,Ke Chen,Yu-Ting Tang,Dongsheng Ji,Hang Xiao,Lei Tong,Chunrong Jia,Qingjun Guo,Jun He
标识
DOI:10.1016/j.scitotenv.2023.167762
摘要
Numerous studies have extensively examined the risk of lung cancer associated with polycyclic aromatic hydrocarbons (PAHs), with particular emphasis on the 16 priority PAHs. However, this may underestimate the actual risk. This study seeks to enhance the current risk assessment framework by integrating four additional parent PAHs such as Dibenzo[a,h]pyrene, Dibenzo[a,l]pyrene, Dibenzo[a,e]pyrene, 7H-benzo[c]fluorene with potentially high risk of causing cancer. By considering their physicochemical properties, metabolism, and bioavailability, the study also examines the relationship between low molecular weight (LMW) - and high molecular weight (HMW)-PAH doses and the risk of developing cancer in the human lungs. The study was conducted in Ningbo, China and identified five PAH sources: natural gas combustion (NGC), vehicular exhaust (VE), coal combustion (CC), biomass burning (BB), and volatilization of unburnt fuel (VUF). This study emphasizes the elevated risk associated with highly carcinogenic PAHs, as they consistently exceed acceptable limits for lung cancer risk throughout the year. Based on the study's estimation, approximately 324 out of every one million individuals exposed to PAHs face an increased cancer risk over their lifetime. This research emphasizes the importance of identifying source specific lung cancer risk in residential areas to protect the exposed population. Moreover, while there is a moderate connection between LMW-PAH doses and lung cancer risk, a strong relationship is observed with HMW-PAHs.
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